Effects of aging and caloric restriction on hepatic drug metabolizing enzymes in the Fischer 344 rat. II: Effects on conjugating enzymes

Mechanisms of Ageing and Development
J E LeakeyR W Hart

Abstract

The effects of long-term caloric restriction on the hepatic phase II drug metabolizing enzymes were investigated in the male Fischer 344 rat. Rats that had been restricted to 60% of their pair-fed control consumption from 14 weeks post-partum exhibited altered conjugating enzyme activities at 22 months. Caloric restriction significantly reduced the age-related decrease in glutathione-S-transferase activity towards 1,2-dichloro-4-nitrobenzene, but did not significantly alter the age-related changes in UDP-glucuronyltransferase or sulfotransferase activities towards hydroxysteroids. Caloric restriction appeared to increase hepatic microsomal UDP-glucuronyltransferase activity toward bilirubin and gamma-glutamyltranspeptidase activities. These observations suggest that caloric restriction has multiple effects on the hepatic phase II drug metabolizing enzymes in the rat. Such effects may alter hepatic metabolism and activation or detoxification of drugs and carcinogens.

References

Jan 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·A M BensonW B Jakoby
Jan 1, 1978·Annual Review of Pharmacology and Toxicology·G J Dutton
May 1, 1980·Molecular and Cellular Endocrinology·M C BillonJ Hanoune
Jan 1, 1983·Neurochemistry International·B A WeissmanY Sarne

❮ Previous
Next ❯

Citations

Oct 1, 1994·The International Journal of Biochemistry·M Matsui, H Homma
Nov 30, 1988·Mechanisms of Ageing and Development·G J SarkisL A Jacobson
Jun 14, 1991·Mechanisms of Ageing and Development·H E EnescoB P Yu
Sep 1, 1991·Mechanisms of Ageing and Development·J LemayB Tuchweber
May 24, 1996·Mechanisms of Ageing and Development·K U ChuJ C Thompson
May 1, 1994·Archives of Gerontology and Geriatrics·L H ChenD L Snyder
Jan 1, 1994·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·T F BergR W Hart
Jun 1, 1993·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·P MaierJ Schlatter
Dec 1, 1993·Mutation Research·M W ChouR W Hart
Jul 1, 1997·Mechanisms of Ageing and Development·J L PipkinD A Casciano
Mar 9, 2000·Mechanisms of Ageing and Development·J A Greenberg, C N Boozer
May 31, 1994·Annals of the New York Academy of Sciences·J E LeakeyR W Hart
Apr 13, 2010·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Yu-Kun Jennifer ZhangCurtis D Klaassen
Mar 1, 1997·Drug Metabolism and Drug Interactions·D V ParkeM Afzal
Sep 10, 2002·The Lancet Oncology·France BianchiniHarri Vainio
Apr 1, 1993·Mutation Research·J G ShaddockD A Casciano
Oct 11, 2015·Fundamental & Clinical Pharmacology·John MachSarah N Hilmer
May 19, 2009·The Journal of Nutritional Biochemistry·Bradley W BollingC-Y Oliver Chen
Mar 15, 1990·Toxicology and Applied Pharmacology·D C McMillanJ A Hinson
Mar 29, 1991·Biochemical and Biophysical Research Communications·M Runge-Morris, J Wilusz
Jun 1, 1994·Chemico-biological Interactions·M A Runge-Morris
Feb 24, 2015·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Jérôme SpitzAndrew W Trites
Oct 1, 2016·Redox Biology·Nicholas O ThomasTory M Hagen
Jan 1, 1994·Drug Metabolism Reviews·D V Parke, C Ioannides
Jul 1, 1997·Applied and Environmental Microbiology·L BezalelC E Cerniglia

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antiparasitics

Antiparasitics are medications which are indicated for the treatment of parasitic diseases. Discover the latest research on antiparasitics here.