Effects of aging and hypertension on the microcirculation

Hypertension
Martin A JamesAngela C Shore

Abstract

Alterations of structure and function of the microcirculation in hypertension in the elderly and changes with normotensive aging have not been fully clarified. We studied capillary pressure, density, and skin microvascular function in 46 subjects in 3 groups: elderly subjects (aged >60 years) with untreated hypertension (n=16), elderly normotensive subjects (n=16), and young normotensive subjects (age <45 years, n=14). In a subgroup of 19 subjects, we also studied resistance artery function in the isometric myograph. Capillary pressure was higher in both elderly groups (elderly hypertensives: 18.6+/-4.7 mm Hg, elderly normotensives: 17.6+/-4.0 mm Hg) compared with young normotensives (13.9+/-2.6 mm Hg, P<0.05), but capillary density did not differ between the groups. Skin vasodilating responses to acetylcholine were greater in young normotensives compared with both elderly groups (P<0.05). In isolated resistance arteries, there was a greater inhibitory effect from blockade of the l-arginine-NO pathway in elderly normotensives (P<0.05) and a reduction in the maximal inhibitory effect of combined blockade of NO, prostanoids, and endothelium-derived hyperpolarizing factor in elderly hypertensives (P<0.05). This study has demonstra...Continue Reading

Citations

Jan 5, 2010·European Journal of Applied Physiology·Garry A TewJohn M Saxton
Jun 2, 2006·The New England Journal of Medicine·Thomas G PickeringDonald Haas
Nov 26, 2013·BMC Complementary and Alternative Medicine·Guangjun WangWeibo Zhang
Jun 29, 2012·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Everett B LohmanSherwine Paul
Oct 10, 2009·The Journal of the Acoustical Society of America·Jiusheng ChenRobin Shandas
Nov 26, 2010·Expert Review of Cardiovascular Therapy·Motoki Fukutomi, Kazuomi Kario
Feb 8, 2011·Microvascular Research·Markos Klonizakis, Edward Winter
Jul 8, 2009·Atherosclerosis·Anna TahvanainenIlkka Pörsti
Jan 29, 2009·Medicina clínica·Carmen MingoranceMaría Alvarez De Sotomayor
Sep 2, 2008·Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association·Takahisa SashoKazuhisa Takahashi
Dec 2, 2008·Experimental Physiology·Phillip E GatesAngela C Shore
Jul 17, 2015·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Vanina S Kanoore EdulArnaldo Dubin
Aug 1, 2014·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Kyle A CarverE Ann Tallant
Jul 3, 2007·Journal of the American College of Cardiology·Michael F O'Rourke, Junichiro Hashimoto
Apr 4, 2015·Current Hypertension Reports·Areti TriantafyllouStella Douma
Nov 2, 2016·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Erik J Behringer
Jun 12, 2013·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Daniel E Forman, Richert E Goyette
Sep 25, 2016·American Journal of Physiology. Heart and Circulatory Physiology·J S BellC P Winlove
Jan 24, 2009·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·S Malek-khosraviG Atefi
Mar 30, 2012·The Journal of Nutrition, Health & Aging·G A TewG J Hodges
May 11, 2019·Clinical Physiology and Functional Imaging·Peter HenrikssonAnna Freyschuss
Aug 22, 2012·Journal of Toxicologic Pathology·Masako ImaokaAtsushi Sanbuissho
Nov 6, 2020·Journal of Applied Physiology·Matthew C BabcockKerrie L Moreau

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.