Sep 1, 1986

Effects of aging and long term dietary intervention on protein turnover and growth of ventricular muscle in the rat heart

Cardiovascular Research
D F GoldspinkB J Merry

Abstract

The developmental growth of the combined right and left ventricles was followed from weaning to senility in rats receiving an unrestricted diet (controls) or pair fed to one half of this food intake. The normal developmental increases in the ventricular weight, protein mass, and nucleic acid contents were retarded by this long term dietary regimen. Although the same maximum values for each variable were ultimately reached in the ventricles of the calorie restricted animals, these were achieved approximately one year later (that is, well into the extended lifespan afforded by such underfeeding). This nutritional slowing of cardiac growth was explained by a retarding of the normal developmental decline in the fractional rates of protein synthesis and protein breakdown (measured in vivo). In the control animals a net loss of ventricular protein occurred over the second year, and this might possibly be associated with a decrease in the mechanical efficiency of the aging heart. Although a similar aging atrophy was found in the ventricles of the diet restricted rats, it was delayed by a year and may be an important factor contributing to the increased longevity. This dietary intervention appears to slow the normal age related changes...Continue Reading

  • References
  • Citations15

References

  • We're still populating references for this paper, please check back later.
  • References
  • Citations15

Citations

Mentioned in this Paper

Developmental Growth
In Vivo
Dietary Modification
Protein Degradation, Regulatory
Diet
Left Ventricular Structure
August Rats
Ventricular Hemorrhage
Protein Degradation, Metabolic
Myocardium

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

Head And Neck Squamous Cell Carcinoma

Squamous cell carcinomas account for >90% of all tumors in the head and neck region. Head and neck squamous cell carcinoma incidence has increased dramatically recently with little improvement in patient outcomes. Here is the latest research on this aggressive malignancy.

Signaling in Adult Neurogenesis

Neural stem cells play a critical role in the production of neuronal cells in neurogenesis is of great importance. Of interest is the role signalling mechanisms in adult neurogenesis. Discover the latest research on signalling in adult neurogenesis.

Psychiatric Chronotherapy

Psychiatric Chronotherapy considers the circadian rhythm as a major factor for optimizing therapeutic efficacy of psychiatric interventions. Discover the latest research on Psychiatric Chronotherapy here.

Bone Marrow Neoplasms

Bone Marrow Neoplasms are cancers that occur in the bone marrow. Discover the latest research on Bone Marrow Neoplasms here.

IGA Glomerulonephritis

IgA glomerulonephritis is a chronic form of glomerulonephritis characterized by deposits of predominantly Iimmunoglobin A in the mesangial area. Discover the latest research on IgA glomerulonephritis here.

Cryogenic Electron Microscopy

Cryogenic electron microscopy (Cryo-EM) allows the determination of biological macromolecules and their assemblies at a near-atomic resolution. Here is the latest research.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.