Effects of aging and methionine restriction applied at old age on ROS generation and oxidative damage in rat liver mitochondria

Biogerontology
Ines Sanchez-RomanGustavo Barja

Abstract

It is known that a global decrease in food ingestion (dietary restriction, DR) lowers mitochondrial ROS generation (mitROS) and oxidative stress in young immature rats. This seems to be caused by the decreased methionine ingestion of DR animals. This is interesting since isocaloric methionine restriction in the diet (MetR) also increases, like DR, rodent maximum longevity. However, it is not known if old rats maintain the capacity to lower mitROS generation and oxidative stress in response to MetR similarly to young immature animals, and whether MetR implemented at old age can reverse aging-related variations in oxidative stress. In this investigation the effects of aging and 7 weeks of MetR were investigated in liver mitochondria of Wistar rats. MetR implemented at old age decreased mitROS generation, percent free radical leak at the respiratory chain and mtDNA oxidative damage without changing oxygen consumption. Protein oxidation, lipoxidation and glycoxidation increased with age, and MetR in old rats partially or totally reversed these age-related increases. Aging increased the amount of SIRT1, and MetR decreased SIRT1 and TFAM and increased complex IV. No changes were observed in the protein amounts of PGC1, Nrf2, MnSOD, A...Continue Reading

References

Apr 1, 1972·Journal of the American Geriatrics Society·D Harman
Dec 1, 1994·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·J P RichieJ A Zimmerman
Feb 1, 1996·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·J G de la AsuncionJ Viña
May 20, 1998·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·R Perez-CampoG Barja
Jun 8, 2001·Mechanisms of Ageing and Development·J M DhahbiS R Spindler
Jun 28, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·R GredillaG Barja
Apr 27, 2002·Annals of the New York Academy of Sciences·Reinald PamplonaManuel Portero-Otín
Aug 13, 2002·Journal of Bioenergetics and Biomembranes·Gustavo Barja
Sep 19, 2002·The Journal of Biological Chemistry·Julie St-PierreMartin D Brand
Jun 12, 2004·Biological Reviews of the Cambridge Philosophical Society·Gustavo Barja
Sep 18, 2004·Trends in Neurosciences·Gustavo Barja
Nov 5, 2004·The EMBO Journal·Nicola VahsenGuido Kroemer
Dec 28, 2004·Ageing Research Reviews·Sang-Kyu Park, Tomas A Prolla
May 28, 2005·Endocrinology·Ricardo Gredilla, Gustavo Barja
Jun 9, 2005·The American Journal of Clinical Nutrition·P K NewbyAlicja Wolk
Feb 1, 2006·Proceedings of the National Academy of Sciences of the United States of America·G López-LluchR de Cabo
Nov 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·A LatorreF J Ayala
Apr 18, 2006·Mechanisms of Ageing and Development·Kyung-Jin Min, Marc Tatar
Jun 29, 2006·Annals of the New York Academy of Sciences·Alberto SanzGustavo Barja
Aug 24, 2006·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Alan G Porter, Alexander G L Urbano
Sep 14, 2006·Annual Review of Pharmacology and Toxicology·Thomas W KenslerShyam Biswal
Dec 1, 2006·Journal of Bioenergetics and Biomembranes·A SanzG Barja
Feb 3, 2007·Science·György Hajnóczky, Jan B Hoek
Apr 25, 2007·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Victoria AyalaReinald Pamplona
Nov 9, 2007·Annual Review of Physiology·Akiko Taguchi, Morris F White
Apr 1, 2008·Annual Review of Biochemistry·William Mair, Andrew Dillin
May 6, 2009·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Liou SunJames M Harper
Jul 7, 2009·Annual Review of Physiology·M Benjamin Hock, Anastasia Kralli
Feb 17, 2010·Biogerontology·L RobertA M Robert
Apr 17, 2010·Science·Luigi FontanaValter D Longo
May 4, 2010·Proceedings of the National Academy of Sciences of the United States of America·Alberto SanzHoward T Jacobs
May 8, 2010·Antioxidants & Redox Signaling·John D HayesAlbena T Dinkova-Kostova
Jun 12, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Barbara E HasekThomas W Gettys
Jul 6, 2010·Biogerontology·Giuseppe PassarinoDina Bellizzi
Aug 28, 2010·Science·Joseph A BaurEric Verdin

❮ Previous
Next ❯

Citations

May 1, 2015·Muscle & Nerve·Cory M DunganDavid L Williamson
Oct 24, 2014·Aging Cell·Dongyeop LeeSeung-Jae Lee
Mar 21, 2016·Annals of the New York Academy of Sciences·R Scott McIsaacRochelle Buffenstein
Feb 27, 2016·Annals of the New York Academy of Sciences·Gene P AblesSailendra N Nichenametla
Jun 12, 2013·Cell·Carlos López-OtínGuido Kroemer
Dec 19, 2015·Oxidative Medicine and Cellular Longevity·Júlia SantosCecília Leão
Jun 10, 2014·Dose-response : a Publication of International Hormesis Society·Michael Ristow, Kathrin Schmeisser
Mar 5, 2013·Experimental Gerontology·Ines Sanchez-Roman, Gustavo Barja
Jan 7, 2014·Mechanisms of Ageing and Development·Maria Giulia BacaliniPaolo Garagnani
Aug 30, 2016·Ageing Research Reviews·Holly M Brown-Borg, Rochelle Buffenstein
Jun 14, 2013·Experimental Biology and Medicine·Sreenivasa MaddineniJohn P Richie
Jan 22, 2017·Experimental Gerontology·Gene P Ables, Jay E Johnson
Dec 1, 2017·Antioxidants & Redox Signaling·María A Pajares, Dolores Pérez-Sala
Feb 6, 2018·Annals of the New York Academy of Sciences·Zhen DongJohn P Richie
Apr 1, 2018·Molecular Nutrition & Food Research·Jie YinYulong Yin
Nov 8, 2018·The British Journal of Nutrition·Si-Yang WangXiang-Mei Chen
Dec 19, 2014·Biochemistry. Biokhimii︠a︡·M V SkulachevV P Skulachev
Mar 1, 2018·Biochemistry. Biokhimii︠a︡·M V Skulachev, V P Skulachev
Aug 25, 2018·Dose-response : a Publication of International Hormesis Society·Rehana K LeakMelvin E Andersen
Oct 13, 2018·International Journal of Molecular Sciences·Kuniyasu Soda
Sep 15, 2020·Functional Ecology·Luke A HoekstraAnne M Bronikowski
Nov 19, 2020·Antioxidants·Mariona JovéReinald Pamplona

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.