Effects of aging on basement membrane-related gene expression of the skeletal muscle in rats.

Biomedical Research
Yuji KanazawaYasufumi Shigeyoshi

Abstract

The basement membrane (BM), with collagen IV as a major component, plays an important role in the maintenance of muscle structure and its robustness. To investigate the effects of aging on factors related to BM construction, we compared the expression status of these factors in 3- and 20-month-old male Wistar rats. The expression levels of Col4a1 and Col4a2 (encoding collagen IV), Sparc (involved in collagen IV functionalization), and Mmp14 (a collagen IV degradation factor) were decreased. These results suggest that aging suppresses collagen IV synthetic and degradative factors and affects BM-related factors in the steady state.

References

Mar 27, 2002·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·D M RoachP A Cowled
Jan 31, 2003·The Journal of Biological Chemistry·Joshua R Sanes
Nov 1, 2011·Matrix Biology : Journal of the International Society for Matrix Biology·Ildikó Kelemen-ValkonyMátyás Mink
Sep 8, 2012·Current Opinion in Rheumatology·Jeremy D Walston
Oct 2, 2012·Nature·Joe V ChakkalakalAndrew S Brack
Mar 23, 2013·The FEBS Journal·Stefano SchiaffinoMarco Sandri
Oct 19, 2013·Frontiers in Physiology·Evelyn ZacharewiczAaron P Russell
May 15, 2015·American Journal of Physiology. Endocrinology and Metabolism·David C HughesKeith Baar
May 21, 2015·The EMBO Journal·Ana Gutiérrez-FernándezCarlos López-Otín
May 14, 2017·Biochimica Et Biophysica Acta. Molecular Cell Research·Sandra Freitas-RodríguezCarlos López-Otín
Aug 15, 2017·Experimental Gerontology·Yuji KanazawaYasufumi Shigeyoshi
Oct 7, 2017·Developmental Biology·Alexa ChioranMaurice J Ringuette
Jul 4, 2020·Connective Tissue Research·Yuji KanazawaYasufumi Shigeyoshi

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