Effects of aging on functional connectivity of the amygdala during negative evaluation: a network analysis of fMRI data

Neurobiology of Aging
Peggy L St JacquesRoberto Cabeza

Abstract

Previous evidence has suggested both preserved emotional function in aging and age-related differences in emotional processing, but the neural networks underlying such processing alterations in the context of preserved affective function are not clear. Using event-related fMRI, we scanned young and older adults while they made valence ratings for emotional pictures. Behavioral results showed a similar pattern of emotional evaluation, but older adults experienced negatively valenced pictures as being less negative. Consistent with behavioral findings, we identified common activity in the right amygdala, but age-related differences in the functional connectivity of this region with the rest of the brain. Compared to young adults, older adults had greater functional connectivity between the right amygdala and ventral anterior cingulate cortex, possibly reflecting increased emotional regulation. Conversely, older adults showed decreased functional connectivity with posterior brain regions, likely reflecting decreased perceptual processing. Thus, age-related differences in evaluating negatively valenced stimuli might reflect decreased perceptual processing of these stimuli, as well as the engagement of control processes that inhibit...Continue Reading

References

Aug 26, 2009·Journal of the International Neuropsychological Society : JINS·Peggy L St JacquesRoberto Cabeza
Nov 10, 2010·Psychology and Aging·Andrew MienaltowskiMatthew R Hilimire
May 7, 2011·Cognition & Emotion·Cesar F Lima, Sao Luis Castro
Jul 27, 2012·Experimental Aging Research·Sandrine VieillardFrançois Maquestiaux
Jan 24, 2012·Neuropsychology, Development, and Cognition. Section B, Aging, Neuropsychology and Cognition·Jennifer C Tomaszczyk, Myra A Fernandes
Apr 26, 2011·Developmental Neuropsychology·Christina M Leclerc, Elizabeth A Kensinger
Jul 1, 2010·Social Cognitive and Affective Neuroscience·Mariann WeierichLisa Feldman Barrett
Jun 5, 2010·Journal of Cognitive Neuroscience·Yoshiya MoriguchiLisa Feldman Barrett
Sep 8, 2011·Journal of Visualized Experiments : JoVE·Sanda DolcosFlorin Dolcos
May 19, 2011·Journal of Visualized Experiments : JoVE·Andrea ShaferFlorin Dolcos
Feb 25, 2014·Neuropsychology Review·Emily L Dennis, Paul M Thompson
Feb 13, 2016·Frontiers in Aging Neuroscience·Jaime Gomez-RamirezJinglong Wu
May 1, 2012·Neurobiology of Aging·Jill D WaringElizabeth A Kensinger
Oct 6, 2015·Annual Review of Psychology·Mara Mather
Jun 27, 2009·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Donna R AddisElizabeth A Kensinger
Mar 19, 2016·Ageing Research Reviews·Motoaki Sugiura
Jan 24, 2015·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Jonathan G HakunBrian T Gold
Nov 12, 2013·Neurobiology of Aging·Yao-Chu ChenYawei Cheng
May 10, 2011·NeuroImage·Peggy L St JacquesDavid C Rubin
Sep 28, 2010·Neuropsychologia·Maureen RitcheyRoberto Cabeza
Mar 6, 2015·Frontiers in Aging Neuroscience·Sandrine VieillardEmmanuel Bigand
Apr 10, 2014·Frontiers in Psychology·Lisa J BurklundMatthew D Lieberman
Nov 27, 2014·Frontiers in Integrative Neuroscience·Florin DolcosMara Mather
Dec 10, 2014·International Journal of Aging & Human Development·Xianmin GongZhiying Long
May 30, 2014·The Quarterly Journal of Experimental Psychology : QJEP·Sandrine Vieillard, Emmanuel Bigand
May 12, 2016·Neuroscience and Biobehavioral Reviews·I García-GarcíaJ Neumann
Dec 18, 2015·PloS One·Jake R Carpenter-ThompsonFatima T Husain
Dec 1, 2011·Cerebral Cortex·R Nathan Spreng, Daniel L Schacter
Jul 1, 2013·Emotion Review : Journal of the International Society for Research on Emotion·Derek M IsaacowitzSheri L Johnson

Citations

Mar 1, 1991·Psychology and Aging·R W LevensonP Ekman
Jul 1, 1997·The Journal of Neuropsychiatry and Clinical Neurosciences·H S Mayberg
Oct 6, 1997·Psychology and Aging·L J Levine, S Bluck
May 29, 2000·Trends in Cognitive Sciences·G BushM I Posner
Jan 3, 2001·NeuroImage·S A HuettelGregory McCarthy
Aug 17, 2001·Journal of Cognitive Neuroscience·R L BucknerJ C Morris
Apr 6, 2002·Psychological Science·Stephan B HamannClinton D Kilts
Aug 15, 2002·Proceedings of the National Academy of Sciences of the United States of America·Hiroshi YamasakiGregory McCarthy
Nov 12, 2002·The Journals of Gerontology. Series B, Psychological Sciences and Social Sciences·Louise H PhillipsRoy Allen
Dec 31, 2002·Brain Research. Brain Research Reviews·David H Zald
Apr 2, 2003·NeuroImage·Stephan F TaylorIsrael Liberzon
Aug 22, 2003·Psychological Science·Mara Mather, Laura L Carstensen
Aug 30, 2003·Biological Psychiatry·Mary L PhillipsRichard Lane
Sep 23, 2003·Emotion·Natalie L DenburgRalph Adolphs
Dec 16, 2003·Cognitive, Affective & Behavioral Neuroscience·Fionnuala C MurphyAndrew D Lawrence
Mar 27, 2004·Psychological Science·Mara MatherLaura L Carstensen
May 18, 2004·Brain Research. Brain Research Reviews·Daan BaasRené S Kahn
Oct 19, 2004·NeuroImage·Jesse RissmanMark D'Esposito
Oct 21, 2004·Nature Neuroscience·Patrik VuilleumierRaymond J Dolan
Oct 28, 2004·Nature Neuroscience·Ralph Adolphs
Feb 11, 2005·Proceedings of the National Academy of Sciences of the United States of America·Florin DolcosRoberto Cabeza
Apr 16, 2005·Current Opinion in Neurobiology·Patricia A Reuter-Lorenz, Cindy Lustig
Apr 27, 2005·Human Brain Mapping·Stuart M GrieveEvian Gordon
May 4, 2005·Trends in Cognitive Sciences·K N Ochsner, J J Gross
Jun 7, 2005·Psychiatry Research·Alessandro TessitoreVenkata S Mattay
Jul 5, 2005·Neuroscience Letters·Håkan FischerLars Bäckman
Sep 9, 2005·Experimental Aging Research·Richard W BacksKyunghee Han
Sep 13, 2005·Trends in Cognitive Sciences·Mara Mather, Laura L Carstensen
Jan 10, 2006·Neurobiology of Aging·Christopher I WrightMarilyn S Albert
Jan 10, 2006·The Journals of Gerontology. Series B, Psychological Sciences and Social Sciences·Mara Mather, Marisa R Knight
Apr 6, 2006·Psychology and Aging·Derek M IsaacowitzHugh R Wilson
Apr 21, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Heather L UrryRichard J Davidson
Jun 2, 2006·Journal of Neurophysiology·S M DaselaarR Cabeza
Jun 16, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Leanne M WilliamsEvian Gordon
Sep 7, 2006·Psychology and Aging·Michelle L KeightleyCheryl L Grady

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