Effects of aging on human leukocytes (part II): immunophenotyping of adaptive immune B and T cell subsets

Age
Ulrik StervboAndreas Thiel

Abstract

Immunosenescence results from a continuous deterioration of immune responses resulting in a decreased response to vaccines. A well-described age-related alteration of the immune system is the decrease of de novo generation of T and B cells. In addition, the accumulation of memory cells and loss of diversity in antigen specificities resulting from a lifetime of exposure to pathogens has also been described. However, the effect of aging on subsets of γδTCR(+) T cells and Tregs has been poorly described, and the efficacy of the recall response to common persistent infections in the elderly remains obscure. Here, we investigated alterations in the subpopulations of the B and T cells among 24 healthy young (aged 19-30) and 26 healthy elderly (aged 53-67) individuals. The analysis was performed by flow cytometry using freshly collected peripheral blood. γδTCR(+) T cells were overall decreased, while CD4(+)CD8(-) cells among γδTCR(+) T cells were increased in the elderly. Helios(+)Foxp3(+) and Helios(-)Foxp3(+) Treg cells were unaffected with age. Recent thymic emigrants, based on CD31 expression, were decreased among the Helios(+)Foxp3(+), but not the Helios(-)Foxp3(+) cell populations. We observed a decrease in Adenovirus-specific C...Continue Reading

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Citations

Dec 8, 2015·Age·Kilian Wistuba-Hamprecht, Graham Pawelec
Apr 20, 2017·Anais Da Academia Brasileira De Ciências·Eduardo FuentesIván Palomo
Sep 5, 2017·F1000Research·Graham Pawelec
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Sep 20, 2020·Mechanisms of Ageing and Development·Graham PawelecAlan A Cohen
Apr 19, 2021·Clinical and Experimental Immunology·Mattia Emanuela LigottiGiuseppina Candore

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