Effects of Aging on Neural Stem/Progenitor Cells and Oligodendrocyte Precursor Cells After Focal Cerebral Ischemia in Spontaneously Hypertensive Rats

Cell Transplantation
Anna C LiangKen Arai

Abstract

Aging and vascular comorbidities such as hypertension comprise critical cofactors that influence how the brain responds to stroke. Ischemic stress induces neurogenesis and oligodendrogenesis in younger brains. However, it remains unclear whether these compensatory mechanisms can be maintained even under pathologically hypertensive and aged states. To clarify the age-related remodeling capacity after stroke under hypertensive conditions, we assessed infarct volume, behavioral outcomes, and surrogate markers of neurogenesis and oligodendrogenesis in acute and subacute phases after transient focal cerebral ischemia in 3- and 12-month-old spontaneously hypertensive rats (SHRs). Hematoxylin and eosin staining showed that 3- and 12-month-old SHRs exhibited similar infarction volumes at both 3 and 14 days after focal cerebral ischemia. However, recovery of behavioral deficits (neurological score assessment and adhesive removal test) was significantly less in 12-month-old SHRs compared to 3-month-old SHRs. Concomitantly, numbers of nestin(+) neural stem/progenitor cells (NSPCs) near the infarct border area or subventricular zone in 12-month-old SHRs were lower than 3-month-old SHRs at day 3. Similarly, numbers of PDGFR-α(+) oligodendro...Continue Reading

References

Nov 1, 1991·Stroke; a Journal of Cerebral Circulation·H YaoM Fujishima
Jun 17, 2005·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Golo KronenbergMatthias Endres
Apr 21, 2009·Lancet Neurology·Zheng Gang Zhang, Michael Chopp
Oct 10, 2009·Proceedings of the National Academy of Sciences of the United States of America·Viktor SkiharV Wee Yong
Oct 15, 2009·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Nobukazu MiyamotoTakao Urabe
Dec 17, 2009·Neurobiology of Aging·Josephine WalterChristoph Redecker
Jul 31, 2010·Neuron·Michael A MoskowitzCostantino Iadecola
Jul 23, 2011·Stroke; a Journal of Cerebral Circulation·Philip B GorelickUNKNOWN American Heart Association Stroke Council, Council on Epidemiology and Prevention, Council on Cardiovascular Nursing, Counci
Jan 13, 2012·Neurology·M KnoflachUNKNOWN Austrian Stroke Unit Registry Collaborators
Jun 16, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yoshihiro MurataEng H Lo
Jul 23, 2013·Stroke; a Journal of Cerebral Circulation·Shira Rosenzweig, S Thomas Carmichael
Aug 21, 2013·Experimental Neurology·Elga EspositoEng H Lo

❮ Previous
Next ❯

Citations

Apr 20, 2017·Journal of Pineal Research·Miguel Mendivil-PerezGermaine Escames
Jun 30, 2016·Stroke; a Journal of Cerebral Circulation·Ulrich Dirnagl
Feb 5, 2019·Expert Opinion on Drug Discovery·Dirk M HermannThorsten R Doeppner
Mar 22, 2019·Stroke; a Journal of Cerebral Circulation·Dirk M Hermann, Christoph Kleinschnitz
Jun 10, 2018·Nature Communications·L CaraccioloS T Carmichael
Aug 1, 2020·Frontiers in Neurology·Jorge Matías-GuiuUlises Gómez-Pinedo
Oct 31, 2020·Cellular and Molecular Neurobiology·Chengli LiuWei Wang

❮ Previous
Next ❯

Methods Mentioned

BETA
Protein
electrophoresis

Software Mentioned

ImageJ

Related Concepts

Related Feeds

Brain Aging

Here is the latest research on intrinsic and extrinsic factors, as well as pathways and mechanisms that underlie aging in the central nervous system.

Aging-Associated Metabolic Disorders

Age is associated with many metabolic disorders including cardiovascular diseases, type 2 diabetes, stroke and heart disease. The mediators in aging process have been suggested to play a part in the cellular processes responsible for these metabolic disorders. Here is the latest research on aging-associated metabolic disorders.

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.