Effects of aging on numbers and sizes of neurons in histochemically defined subregions of monkey striate cortex

The Anatomical Record
C B KimP D Spear

Abstract

In addition to its horizontal layers, primate striate cortex has a vertical modular organization. Among the vertical modules are histochemically defined areas of high and low cytochrome oxidase labeling in the supragranular layers, referred to, respectively, as blobs and interblobs. Cytochrome c oxidase (CO) blobs and interblobs differ in their inputs from the magnocellular and parvocellular visual pathways, their physiological properties, and many aspects of their neurochemistry. The present study investigated whether aging differentially affects neuron numbers or sizes in the supragranular blobs or interblobs. The right hemisphere from three young adult (5.2-12.4 years) and four old (24.0-26.7 years) rhesus monkeys was used. Tangential sections through the central visual-field representation were stained for CO and counterstained with cresyl violet. Montages were constructed through cortical layers 2 and 3, and neuron counts and size measurements were made in blob and interblob regions using stereological procedures that yield unbiased estimates. Blob density also was calculated. CO blob density was 3.76/mm2 in young adults and 3.95/mm2 in old animals, a difference that was not statistically significant. Neuron soma sizes als...Continue Reading

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Oct 15, 2008·PloS One·Marianne David-JürgensHubert R Dinse
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