PMID: 8951457Dec 1, 1996Paper

Effects of aging on potassium homeostasis and the endocochlear potential in the gerbil cochlea

Hearing Research
R A Schmiedt

Abstract

Previous work has shown that the endocochlear potential (EP) decreases with age in the gerbil. Concomitant with the EP decrease is an age-related loss of activity of Na,K-ATPase in the lateral wall and stria vascularis. We hypothesized that the EP decrease is associated with a similar decrease in the endolymphatic potassium concentration [Ke+]. This hypothesis was tested using double-barrelled, K(+)-selective electrodes introduced into scala media through the round window in young and quiet-aged gerbils. Results show that the means (+/- S.D.) of the [Ke+] in young and aged gerbils were not significantly different (178.2 +/- 14.2 mM and 171.2 +/- 34.4 mM, respectively), although the intersubject variability was much greater in the aged animals than in the young. These values of [Ke+] are slightly higher than those found for other mammals and may reflect the higher plasma osmolarity found in the gerbil. The concentration of perilymphatic potassium [Kp+] in scala tympani at the round window was also similar for the young and aged groups (3.57 +/- 1.17 mM and 4.18 +/- 2.03 mM, respectively). On the other hand, mean EP values in the young and aged gerbils were 92.0 +/- 5.7 mV and 64.8 +/- 15.8 mV, respectively and were statistically...Continue Reading

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Citations

Aug 29, 2003·Journal of the Association for Research in Otolaryngology : JARO·H LangR A Schmiedt
Dec 24, 2003·Journal of the Association for Research in Otolaryngology : JARO·Tao Wu, Daniel C Marcus
Nov 8, 2003·Journal of the Association for Research in Otolaryngology : JARO·David M Mills, Richard A Schmiedt
Apr 8, 2010·Journal of the Association for Research in Otolaryngology : JARO·Hainan LangRichard A Schmiedt
Apr 25, 2012·Journal of the Association for Research in Otolaryngology : JARO·Enrique A Lopez-Poveda, Peter T Johannesen
Jun 7, 2013·Journal of the Association for Research in Otolaryngology : JARO·Judy R DubnoRichard A Schmiedt
Feb 5, 2004·Hearing Research·Brian C J Moore, Brian R Glasberg
Jan 1, 1999·Hearing Research·Y ZhengT Takasaka
Nov 5, 1999·Hearing Research·U LangemannA Friebe
Jun 25, 2014·Clinical Interventions in Aging·Grażyna LisowskaMaciej Misiolek
Feb 23, 2012·The Journal of the Acoustical Society of America·Brian C J MooreKathryn Hopkins
Oct 17, 2002·Journal of the Association for Research in Otolaryngology : JARO·R A SchmiedtB A Schulte
Dec 27, 2015·Hearing Research·Anthony MyintRick A Friedman
Jun 25, 2008·Hearing Research·Su-Hua ShaJochen Schacht
May 30, 2008·Hearing Research·Eric C BielefeldDonald Henderson
Jul 31, 2007·Experimental Cell Research·Xianzhi NiuBarbara Canlon
Feb 9, 2006·Neurobiology of Aging·Jiri PopelarJosef Syka
Feb 21, 2013·Hearing Research·Tatsuya YamasobaKenji Kondo
Jun 17, 2008·Otolaryngologia polska. The Polish otolaryngology·Grazyna LisowskaEugeniusz Czecior
Aug 30, 2016·Experimental Gerontology·Otto GleichJürgen Strutz
Jan 13, 2004·The Journal of the Acoustical Society of America·Martina Huss, Brian C J Moore
Oct 16, 2014·Trends in Hearing·Brian C J Moore
Jan 28, 2003·Journal of Speech, Language, and Hearing Research : JSLHR·Flint A Boettcher
Nov 6, 2009·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Roberto TeggiMario Bussi
Nov 26, 2019·Journal of Neuroscience Research·Anwen BullenRuth Taylor
May 9, 2019·Journal of Neuroscience Research·Elizabeth M Keithley
Nov 11, 2016·Journal of the Association for Research in Otolaryngology : JARO·Kenneth I VadenJudy R Dubno
Jul 18, 2017·Anatomy & Cell Biology·Kwon Young LeeJung Hoon Choi
Nov 25, 2020·Proceedings of the National Academy of Sciences of the United States of America·Sophie BoucherChristine Petit

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