PMID: 3384028Jan 1, 1988Paper

Effects of aging on respiration, ATP levels and calcium transport in rat liver mitochondria. Response to theophylline

Experimental Gerontology
J AlemanyJ Miquel

Abstract

The concept that aging results in an impairment of mitochondrial biochemistry has been tested on organelles isolated from the liver of 3-4-month-old and 24-month-old rats of the Wistar strain. Our data suggest that aging results in significant decreases in succinate-supported respiration, ATP levels and calcium uptake. When theophylline was added to the incubation mixture, both respiration and calcium uptake were depressed in approximately the same proportion in the mitochondria from old rats, although the mitochondrial ATP of young animals was significantly decreased by this substance.

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Citations

Jan 1, 1990·The International Journal of Biochemistry·J de la CruzI Roncero
Jan 1, 1991·Archives of Gerontology and Geriatrics·I RonceroM J de la Cruz
Mar 24, 1998·Mechanisms of Ageing and Development·S IossaG Liverini
Oct 3, 2012·Antioxidants & Redox Signaling·Daniel A PulliamHolly Van Remmen
Jul 16, 2005·American Journal of Physiology. Gastrointestinal and Liver Physiology·Alan CahillPeter Sykora
Oct 27, 2011·Experimental Gerontology·María del R CastroSylvette Ayala-Torres
Dec 19, 1998·Cell Biochemistry and Function·S IossaG Liverini
Dec 29, 1989·Biochemical and Biophysical Research Communications·T C YenY H Wei
Oct 17, 2021·Amino Acids·Takumi TerataniJoji Kitayama

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