PMID: 2109940Apr 1, 1990Paper

Effects of aging on responses of cerebral arterioles

The American Journal of Physiology
W G MayhanD D Heistad

Abstract

Our goal was to determine whether responses of cerebral arterioles are altered in aged rats. We examined responses of cerebral arterioles in adult (6-8 mo old) and aged (22-24) mo old) Wistar rats to superfusion of acetylcholine and bradykinin, which presumably produce dilatation by releasing an endothelium-derived relaxing factor (EDRF), and to nitroglycerin, which produces dilatation by a direct effect on vascular muscle. In adult rats, cerebral arterioles dilated by 11 +/- 2% (SE) to acetylcholine (10(-5) M) and by 21 +/- 3% to bradykinin (10(-7) M). In contrast, arterioles in aged rats dilated by only 3 +/- 1% to acetylcholine and by 7 +/- 3% to bradykinin. Vasodilatation in response to nitroglycerin was similar to adult and aged rats. We also examined responses of cerebral arterioles to products released by platelets (ADP, serotonin, and thromboxane). ADP (10(-4) M) increased pial arteriolar diameter by 26 +/- 5% in adults rats and only 12 +/- 3% in aged rats. Serotonin (10(-5) M) produced modest vasodilatation in adult rats (7 +/- 1%) but modest vasoconstriction in aged rats (-5 +/- 2%). Vasoconstriction in response to a thromboxane A2 analogue (U 46619) was similar in adult and aged rats. Indomethacin (10 mg/kg iv) did n...Continue Reading

Citations

Sep 18, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Judy M Muller-DelpMichael D Delp
Jan 31, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Kathryn A BrownFrank M Faraci
Mar 1, 1994·Stroke; a Journal of Cerebral Circulation·F M Faraci, J E Brian
Apr 12, 2001·American Journal of Physiology. Heart and Circulatory Physiology·J E BrianS A Moore
Feb 23, 2002·Clinical Orthopaedics and Related Research·Susan A BloomfieldMichael D Delp
Mar 10, 2001·Stroke; a Journal of Cerebral Circulation·M NakajimaT Ohmoto
May 17, 2005·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Seiji MaedaMitsuo Matsuda
May 22, 2010·Journal of Applied Physiology·Nisreen Mansour Omar, Janice M Marshall
Jul 1, 1994·Stroke; a Journal of Cerebral Circulation·G L BaumbachD D Heistad
Jun 24, 2003·Journal of Applied Physiology·Greg G Geary, John N Buchholz
Feb 22, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Frank M Faraci
Jul 27, 2014·American Journal of Physiology. Heart and Circulatory Physiology·Ibolya RutkaiDavid W Busija
Jun 14, 2000·American Journal of Physiology. Heart and Circulatory Physiology·R PaternòF M Faraci
Mar 4, 2003·Journal of Applied Physiology·Seiji MaedaMitsuo Matsuda

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