PMID: 9194686Jan 1, 1997Paper

Effects of aging on the activities of pyruvate dehydrogenase complex and its kinase in rat heart

Life Sciences
N NakaiY Shimomura

Abstract

Effects of aging on the activities of heart pyruvate dehydrogenase complex and pyruvate dehydrogenase kinase were examined using 7, 35 and 60 wk old rats. Aging did not affect the total activity of pyruvate dehydrogenase complex but decreased the activity state (percentage of active form) of the complex in rats under the fed condition (52%, 36% and 26% for 7, 35 and 60 wk old rats, respectively). This decrease in the complex activity with aging was suggested to be associated with an age-related decrease in the blood glucose disposal. Starvation for 24 h decreased the activity state to less than 3% in all of the age groups. The activity of pyruvate dehydrogenase kinase associated with the complex was not related to the alteration in the activity state of the complex; the kinase activity was slightly lower in 60 wk old rats than in the younger rats under the fed condition and activation of the kinase by starvation was greater in the younger rats. The mechanism for the decrease in activity of pyruvate dehydrogenase complex was discussed on the basis of glucose and fatty acid utilization of heart muscle cells.

References

Dec 1, 1992·Journal of Applied Physiology·K YamanouchiM Higuchi
Jan 15, 1989·The Biochemical Journal·D R MarchingtonP J Randle
Mar 1, 1983·The American Journal of Physiology·S R Goodman, K Shiffer
Jan 1, 1994·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·M C Sugden, M J Holness
Jun 1, 1996·Journal of Applied Physiology·N NakaiY Sato

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Citations

Apr 18, 2003·Archives of Medical Research·Karla Carvajal, Rafael Moreno-Sánchez
Jul 27, 1999·Metabolism: Clinical and Experimental·N NakaiY Shimomura
Mar 22, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·J H SuhT M Hagen
Nov 23, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·B J GurdJ M Kowalchuk

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