Effects of aging on the circadian rhythm of wheel-running activity in C57BL/6 mice

The American Journal of Physiology
Verônica S ValentinuzziF W Turek

Abstract

The effects of age on the circadian clock system have been extensively studied, mainly in two rodent species, the laboratory rat and the golden hamster. However, less information is available on how aging alters circadian rhythmicity in a commonly studied rodent animal model, the mouse. Therefore, in the present study we compared the rhythm of wheel-running activity in adult (6-9 mo) and old (19-22 mo) C57BL/6J mice maintained under different lighting conditions for a period of 4 mo. During this period, mice were subjected to phase advances and phase delays of the light-dark (LD) cycle and eventually to constant darkness (DD). In LD (12 h light, 12 h dark), old mice exhibited delayed activity onset relative to light offset and an increase in the variability of activity onset compared with adult mice. After a 4-h phase advance of the LD cycle, old mice took significantly longer to reentrain their activity rhythm when compared with adult animals. Old mice also demonstrated a decline in the number of wheel revolutions per day and a tendency toward a decrease in the length of the active phase. An increase in fragmentation of activity across the 24-h day was obvious in aging animals, with bouts of activity being shorter and longer r...Continue Reading

References

Jan 1, 1991·Journal of the American Geriatrics Society·M A Brock
Sep 1, 1986·Journal of Gerontology·D K WelshW C Dement
Jan 1, 1982·Neurobiology of Aging·E D WeitzmanJ C Zimmerman
Mar 1, 1995·Physiology & Behavior·B PossidenteA Pabon
Apr 1, 1994·Chronobiology International·W WittingD F Swaab
May 16, 1997·Cell·D P KingJ S Takahashi
Dec 1, 1981·Journal of Comparative Physiology·Fred C Davis, Michael Menaker

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Citations

Oct 22, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Clarke G TankersleyRobert Frank
Apr 16, 2003·Journal of Biological Rhythms·Daniel E KolkerFred W Turek
Jan 1, 2011·Current Protocols in Mouse Biology·Gareth T Banks, Patrick M Nolan
Sep 1, 2016·Addiction Biology·Urszula SkupioRyszard Przewlocki
Jul 3, 2018·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Isa KolbeMarta Garaulet
Jul 30, 2019·Journal of Alzheimer's Disease : JAD·Scott H DeibelRobert J McDonald
Aug 29, 2019·American Journal of Physiology. Renal Physiology·Emily E SchmittDanielle R Bruns
May 25, 2013·Journal of Applied Physiology·Gretchen WolffKaryn A Esser
Nov 5, 2011·Environmental Health and Preventive Medicine·Haruko TakeshitaToru Takeuchi
Jan 5, 2017·BioMed Research International·Yasukazu Nakahata, Yasumasa Bessho
Mar 21, 2020·Frontiers in Physiology·Milena Damulewicz, Gabriella M Mazzotta
Jan 28, 2020·Journal of Biological Rhythms·M Renate BuijinkStephan Michel
Oct 1, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Sibah HasanSimon N Archer
Feb 23, 2019·The European Journal of Neuroscience·Stephan Michel, Johanna H Meijer
Jun 24, 2020·Chronobiology International·Fabiana B GonçalvesCarolina V M Azevedo
Feb 6, 2015·Scandinavian Journal of Medicine & Science in Sports·Z SoffeT Shavlakadze
Nov 4, 2020·Journal of Biological Rhythms·Violetta PilorzHenrik Oster
Apr 16, 2021·Biochemical Pharmacology·M PanagiotouT Deboer
May 6, 2021·Npj Aging and Mechanisms of Disease·Dorela D Shuboni-MulliganDeeDee K Smart
Jul 25, 2019·Journal of Proteome Research·Paula AdlerDaniel Figeys
Aug 15, 2021·Ageing Research Reviews·Siamak Tabibzadeh
Oct 20, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Richard AndersonAnton A Komar

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