Effects of aglépristone, a progesterone receptor antagonist, administered during the early luteal phase in non-pregnant bitches

Theriogenology
S GalacAuke C Okkens

Abstract

Aglépristone, a progesterone receptor antagonist, was administered to six non-pregnant bitches in the early luteal phase in order to determine its effects on the duration of the luteal phase, the interestrous interval, and plasma concentrations of progesterone and prolactin. Aglépristone was administered subcutaneously once daily on two consecutive days in a dose of 10 mg/kg body weight, beginning 12 +/- 1 days after ovulation. Blood samples were collected before, during, and after administration of aglépristone for determination of plasma progesterone and prolactin concentrations. The differences in mean plasma concentration of progesterone and of prolactin before, during, and after treatment were not significant. Also, the duration of the luteal phase in the six treated bitches (72 +/- 6 days) did not differ significantly from that in untreated control dogs (74 +/- 4 days ). However, the intervals during which plasma progesterone concentration exceeded 64 and 32 nmol/l were significantly shorter in the six treated bitches than in untreated control dogs. The interestrous interval was significantly shorter in beagle bitches treated with aglépristone (158 +/- 16 days) than in the same group prior to treatment (200 +/- 5 days ). ...Continue Reading

References

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Citations

Mar 17, 2007·Journal of Comparative Pathology·Y MillánJ Martín de las Mulas
Sep 17, 2009·Reproduction in Domestic Animals = Zuchthygiene·P W Concannon
Sep 6, 2007·The Journal of Small Animal Practice·E RollónJ Martín de las Mulas
Mar 6, 2009·The Journal of Small Animal Practice·C H Pettersson, A Tidholm
Jun 7, 2005·Theriogenology·S GörlingerA C Okkens
Oct 18, 2014·Veterinary Research Communications·Alberto ContriDomenico Robbe
Sep 4, 2015·Biology of Reproduction·Karine ReynaudSylvie Chastant-Maillard
Jul 25, 2008·Reproduction in Domestic Animals = Zuchthygiene·J de GierA C Okkens
Sep 21, 2004·Nature Reviews. Neuroscience·Heinz Wässle
Dec 14, 2019·Journal of Feline Medicine and Surgery·Kubra Karakas AlkanHalit Kanca
Apr 30, 2021·Reproduction in Domestic Animals = Zuchthygiene·Chunsumon LimmanontKaitkanoke Sirinarumitr
Jul 3, 2021·Animals : an Open Access Journal From MDPI·Piotr SochaTomasz Janowski

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