PMID: 22572380May 11, 2012Paper

Effects of AhR ligands on the production of immunoglobulins in purified mouse B cells

Biomedical Research
Takayuki YoshidaTakashi Nishimura

Abstract

The aryl hydrocarbon receptor (AhR) has been shown to play important roles in the immune system, and contributions of AhR ligands to the differentiation and functions of Th17/Treg cells have recently been established. However, it has not been fully clarified whether AhR plays roles in B cell differentiation and functions. The environmental pollutant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), a highly potent AhR agonist, was reported to suppress the production of immunoglobulin M (IgM) in a transformed mouse B cell line. However, TCDD exhibits high toxicity toward cells and has unknown activities except for its action as an AhR agonist. In the present study, we tried to clarify how an endogenously generated AhR agonist affects mouse B cell differentiation and functions in terms of the direct effects on the expression of Ig subclasses in purified mouse B cells stimulated with an anti-CD40 antibody and interleukin-4. The AhR agonist 2-(1'H-indole-3'- carbonyl)-thiazole-4-carboxylic acid methyl ester (ITE), which is derived via tryptophan metabolism, suppressed the expression of not only IgM, but also IgG1 and IgE. ITE was also found to suppress the expression of secreted-type Ig mRNAs and plasma cell-specific genes. These finding...Continue Reading

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Citations

Aug 22, 2013·Seminars in Immunopathology·Celine A Beamer, David M Shepherd
Dec 25, 2012·Transplantation·Michael Van VoorhisJoshua D Mezrich
May 8, 2014·Reproductive Sciences·Kenan OmurtagKelle H Moley
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Jun 29, 2018·Seminars in Immunopathology·Luisa Cervantes-Barragan, Marco Colonna
Jun 17, 2015·Environmental Science & Technology·Jijing TianBin Zhao

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