Effects of albumin and Ringer's lactate on production of lung cytokines and hydrogen peroxide after resuscitated hemorrhage and endotoxemia in rats

Critical Care Medicine
Haibo ZhangArthur S Slutsky

Abstract

Acute lung injury is a frequent complication of severe sepsis or blood loss and is often associated with an excessive inflammatory response requiring mechanical ventilation. We tested the hypothesis that the types of fluids used during early resuscitation have an important effect on the evolution of lung injury. Rats were subjected to either hemorrhage or endotoxemia for 1 hr, followed by resuscitation to a controlled mean blood pressure with Ringer's lactate, 5% albumin, or 25% albumin for 1 hr. After resuscitation, blood cytokine levels were measured. The lung was then excised and ventilated with a tidal volume of 30 mL/kg for 2 hrs. The volume of fluids required was significantly smaller in the albumin-treated groups than in the Ringer's lactate groups. In the hemorrhagic shock model, plasma concentrations of tumor necrosis factor-alpha, interleukin-6, and macrophage inflammatory protein-2 were significantly lower and interleukin-10 was significantly higher in the albumin-treated groups compared with the Ringer's lactate-treated group. The levels of tumor necrosis factor-alpha and macrophage inflammatory protein-2 in bronchoalveolar lavage fluid were lower and interleukin-10 was higher in the albumin-treated groups than in t...Continue Reading

References

Jan 1, 1976·Resuscitation·L O Lamke, S O Liljedahl
May 1, 1992·The American Review of Respiratory Disease·J P MitchellD P Schuster
Jan 1, 1991·The American Journal of Physiology·G BoyarskyW F Boron
Jul 1, 1989·Critical Care Medicine·T E Emerson
Jul 1, 1988·Pharmacological Research Communications·R PirisinoP Barbera
Dec 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·B FreiB N Ames
Aug 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·R StockerB N Ames
Jan 1, 1983·Annual Review of Biochemistry·J Travis, G S Salvesen
Mar 1, 1995·American Journal of Respiratory and Critical Care Medicine·T E StewartA S Slutsky
Apr 1, 1995·Free Radical Biology & Medicine·M B Hampton, C C Winterbourn
Jan 1, 1996·Journal of Neuroimmunology·H E de VriesJ Kuiper
Feb 1, 1997·American Journal of Respiratory Cell and Molecular Biology·R Shenkar, E Abraham
Mar 1, 1997·The Journal of Clinical Investigation·L TremblayA S Slutsky
Jul 24, 1998·BMJ : British Medical Journal·UNKNOWN Cochrane Injuries Group Albumin Reviewers
Dec 7, 2000·Cytokines, Cellular & Molecular Therapy·S SivaramanH D Preisler
Mar 17, 2001·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·J MartinF Beyersdorf
Mar 20, 2001·Critical Care : the Official Journal of the Critical Care Forum·G S Martin
May 15, 2001·American Journal of Physiology. Lung Cellular and Molecular Physiology·S DokkaY Rojanasakul
Aug 16, 2001·American Journal of Physiology. Lung Cellular and Molecular Physiology·Y SongX Meng
Sep 5, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·G W CockerillC Thiemermann
Sep 8, 2001·American Journal of Physiology. Cell Physiology·E FerreroA Corti
Nov 16, 2001·American Journal of Physiology. Heart and Circulatory Physiology·T O NossuliM L Entman
Feb 22, 2002·Vox Sanguinis·M P W Grocott, M A Hamilton

❮ Previous
Next ❯

Citations

Nov 19, 2009·Intensive Care Medicine·Michael JoannidisUNKNOWN Critical Care Nephrology Working Group of the European Society of Intensive Care Medicine
Oct 19, 2010·Journal of Anesthesia·Tomi T NiemiMichiaki Yamakage
Feb 15, 2014·American Journal of Surgery·Undurti N Das
May 24, 2011·Advances in Pharmacological Sciences·Derek S WheelerBasilia Zingarelli
Nov 26, 2004·American Journal of Respiratory and Critical Care Medicine·UNKNOWN American Thoracic Society
Oct 24, 2009·The Tohoku Journal of Experimental Medicine·Marios-Konstantinos TasoulisEmmanuel E Douzinas
Nov 7, 2008·Journal of Zhejiang University. Science. B·Yun ZhangZuo-Bing Chen
Apr 19, 2015·Critical Care : the Official Journal of the Critical Care Forum·Martin SchläpferRichard D Minshall
Feb 9, 2011·Journal of Intensive Care Medicine·Fredric M PieracciErnest E Moore
Oct 12, 2010·Anesthesiology·Xanthippi BalkamouLila Papadimitriou
Dec 24, 2005·Shock·J L Lomas-NieraAlfred Ayala
Apr 19, 2015·Critical Care : the Official Journal of the Critical Care Forum·Undurti N Das
Apr 11, 2006·American Journal of Physiology. Lung Cellular and Molecular Physiology·Lucia de FranceschiCarlo Brugnara
Jan 22, 2005·Seminars in Dialysis·Burl R Don, George Kaysen
Mar 14, 2013·Shock·Fernando Godinho ZampieriLuciano Cesar Pontes Azevedo
Jan 26, 2016·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Toshiaki IbaThachil Jecko
Nov 16, 2006·World Journal of Gastroenterology : WJG·Zuo-Bing ChenYong-Qing Zhou

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition
D B Schwartz, A K Darrow
© 2022 Meta ULC. All rights reserved