Effects of albumin, dextran, and hyaluronidase on pulmonary interstitial conductivity.

Journal of Applied Physiology
S J Lai-FookL V Brown

Abstract

The fluid conductivity of albumin solutions of various concentrations relative to that of saline was measured in the interstitium surrounding a short segment of a large (1.5- to 3-mm-diam) blood vessel of an isolated rabbit lung of which air spaces and vasculature were filled with silicon rubber. At a constant driving pressure, the flow of the following solutions was measured sequentially: normal saline and albumin solution (3, 5.5, 8, or 15 g/100 ml saline), hyaluronidase solution (0.02 g/100 ml), and albumin solution (same concentration used before hyaluronidase solution). The albumin-to-saline flow ratios averaged 1.00 +/- 0.23 (SD), 1.01 +/- 0.21, 1.32 +/- 0.63, and 1.54 +/- 0.36 for albumin concentrations of 3, 5.5, 8, and 15 g/100 ml, respectively. These ratios were higher than the corresponding values of 0.88, 0.78, 0.72, and 0.5 expected if the flow of albumin solution were to depend only on fluid viscosity. The flow of dextran and hyaluronan solutions was more viscosity dependent than the flow of albumin solutions. The increased flow of albumin solution could be the result of a reduced excluded volume of albumin caused by collagen and glycosaminoglycans with an increased albumin concentration. The flow of hyaluronidase...Continue Reading

Citations

Aug 4, 1998·Journal of Applied Physiology·X L QiuS J Lai-Fook
Feb 10, 1999·The American Journal of Physiology·E R ZakariaM F Flessner
Apr 13, 2005·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Peter J Coleman
Sep 22, 2001·AJR. American Journal of Roentgenology·B S KuszykE K Fishman
Feb 16, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Kathryn MaitlandMichael Levin
Jan 1, 2011·Annual Review of Chemical and Biomolecular Engineering·Vikash P ChauhanRakesh K Jain
Jun 6, 1998·American Journal of Respiratory Cell and Molecular Biology·A B Al-MehdiA B Fisher
Aug 10, 2004·Journal of Applied Physiology·P K HoutzS J Lai-Fook
Aug 1, 2006·Journal of Controlled Release : Official Journal of the Controlled Release Society·L H BookbinderG I Frost
Mar 1, 1995·Chest·C R Roberts

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