Effects of alcohol availability, access to alcohol, and naltrexone on self-reported craving and patterns of drinking in response to an alcohol-cue availability procedure.

Journal of Studies on Alcohol and Drugs
Marc I KruseDena Davidson

Abstract

Craving has long been cited by patients and providers as a principal construct in alcohol use disorders and an essential target for treatment. The goal of the current study was to examine the effects of alcohol availability (20% vs. 80% availability), access to alcohol ("open" vs. "locked" trials), and medication (oral naltrexone [Revia] vs. placebo) on self-reported craving and two behavioral measures of drinking (latency of attempt to access alcohol, amount of alcohol consumed when access permitted) in response to an alcohol-cue availability procedure. Non-treatment-seeking, alcohol-dependent men and women (N = 58) self-referred for an alcohol administration study and were administered a modified alcohol-cue availability procedure under two medication conditions (naltrexone, placebo) using a within-subjects, repeated-measures design. Analyses demonstrated that the experimental manipulations used in this study had differential effects on craving and patterns of drinking. Specifically, reduced availability of alcohol (i.e., when alcohol was available in only 20% as opposed to 80% of trials) resulted in greater amounts of alcohol consumed per open trial; the unanticipated blocking of access to alcohol (i.e., a "locked" trial dur...Continue Reading

Citations

Oct 16, 2013·Peptides·Richard J Bodnar
Jan 28, 2015·Alcoholism, Clinical and Experimental Research·Matthew J WorleyRichard Longabaugh
Jan 27, 2015·Clinical Psychology Review·Jennifer C Veilleux, Kayla D Skinner
May 31, 2014·The International Journal on Drug Policy·Jennifer L CremeensMark Jones
Nov 8, 2020·International Journal of Environmental Research and Public Health·Andrea PastorXisca Sureda
Sep 2, 2021·Alcoholism, Clinical and Experimental Research·Courtney A Motschman, Stephen T Tiffany

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