Effects of alcohol on cocaine lethality in rats: acute and chronic assessments

Neurotoxicology and Teratology
Gregory D Busse, Anthony L Riley

Abstract

Cocaine and alcohol is a popular, yet toxic, drug combination that results in effects greater than that of either drug alone. The following experiment presents additional evidence that supports this position. Specifically, the lethal effects of acute (1 day) and chronic (4 days) alcohol (0.5 g/kg), cocaine (20, 30, or 40 mg/kg), or the respective alcohol/cocaine combinations were assessed in rats. For acute drug administration, lethality was only evident in those animals administered the combination of 0.5 g/kg alcohol and 40 mg/kg cocaine, supporting the position that the effects of combining alcohol and cocaine are greater than either drug alone. Chronic drug administration resulted in a weak sensitization to cocaine-induced lethality that was increased when alcohol was combined with cocaine. Together, this evidence suggests that combining alcohol and cocaine (acutely) can have lethal consequences in rats that are greater than either drug alone, effects that can be exacerbated with chronic use.

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Citations

May 24, 2005·Pharmacology, Biochemistry, and Behavior·Gregory D BusseAnthony L Riley
Dec 23, 2003·Progress in Neuro-psychopharmacology & Biological Psychiatry·Gregory D BusseAnthony L Riley
Oct 14, 2009·The European Journal of Neuroscience·Congwu DuHelene Benveniste
Jan 7, 2015·Critical Reviews in Analytical Chemistry·Monika WieczerzakJacek Namieśnik
Aug 23, 2008·Journal of Pharmacological Sciences·Daniela BraidaMariaelvina Sala
Aug 11, 2004·Pharmacology, Biochemistry, and Behavior·Gregory D Busse, Anthony L Riley
Mar 12, 2011·The American Journal of Forensic Medicine and Pathology·D Kimberley Molina, Veronica M Hargrove

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