Feb 1, 1976

Effects of alcohol on ion transport by isolated gastric and esophageal mucosa

Gastroenterology
D Fromm, R Robertson

Abstract

The effects of ethyl alcohol, 20%, were measured on steady state rates of ion transport by isolated mucosa. Luminal, but not serosal, addition of alcohol altered ion transport. Alcohol caused a sustained reduction in apparent basal acid secretion by fundic mucosa. These tissues were resistant to ordinarily effective stimulants of acid secretion (histamine, theophyline, dibutyryl cyclic AMP, and gastrin) by rabbit mucosa. Across antral mucosa, net Na transport was inhibited, and net Cl transport was reduced in the presence of alcohol. The unidirectional fluxes of both ions were increased as was permeability to erythritol. These effects of alcohol did not require the presence of acid in the lumen. The rate of luminal acid loss by antrum was increased by alcohol. Addition of ouabain alone, which inhibits net Na and Cl transport, did not alter the rate of luminal acid loss by antrum. Alcohol, however, still increased the rate of luminal acid loss by antral mucosa treated with ouabain. Alcohol reduced the electrical resistance of fundic and antral mucosa but had no effect on the rate of luminal acid loss or electrical resistance of esophageal mucosa. Luminal application of alcohol inhibits active ion transport in addition to increas...Continue Reading

  • References
  • Citations

References

  • We're still populating references for this paper, please check back later.
  • References
  • Citations

Citations

  • This paper may not have been cited yet.

Mentioned in this Paper

Chloride Ion Level
Ethanol
Gastric Juice
Erythritol
Structure of Pyloric Gland
Ouabain
Sodium
Muscularis Mucosae
Dose-Response Relationship, Drug
Stomach

About this Paper

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Bone Marrow Neoplasms

Bone Marrow Neoplasms are cancers that occur in the bone marrow. Discover the latest research on Bone Marrow Neoplasms here.

IGA Glomerulonephritis

IgA glomerulonephritis is a chronic form of glomerulonephritis characterized by deposits of predominantly Iimmunoglobin A in the mesangial area. Discover the latest research on IgA glomerulonephritis here.

Cryogenic Electron Microscopy

Cryogenic electron microscopy (Cryo-EM) allows the determination of biological macromolecules and their assemblies at a near-atomic resolution. Here is the latest research.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

LRRK2 & Immunity During Infection

Mutations in the LRRK2 gene are a risk-factor for developing Parkinson’s disease. However, LRRK2 has been shown to function as a central regulator of vesicular trafficking, infection, immunity, and inflammation. Here is the latest research on the role of this kinase on immunity during infection.

Antiphospholipid Syndrome

Antiphospholipid syndrome or antiphospholipid antibody syndrome (APS or APLS), is an autoimmune, hypercoagulable state caused by the presence of antibodies directed against phospholipids.

Meningococcal Myelitis

Meningococcal myelitis is characterized by inflammation and myelin damage to the meninges and spinal cord. Discover the latest research on meningococcal myelitis here.

Alzheimer's Disease: MS4A

Variants within membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease by recent genome-wide association studies. Here is the latest research.