PMID: 9192169Jun 1, 1997Paper

Effects of aldose reductase inhibitor CT-112 on the corneal epithelial barrier of galactose-fed rats

Current Eye Research
N YokoiS Kinoshita

Abstract

To investigate whether the barrier function of the corneal epithelium is disrupted in galactosemic rats, and to assess the effects of the aldose reductase inhibitor CT-112, in the form of eyedrops, on the corneal epithelial barrier in galactosemic rats. Forty rats were divided into 3 groups based on their diet: a control group, a galactose group and a CT-112 treated galactose group (CT-112 group). After 3 weeks, 31 rats from the 3 groups were subjected to fluorophotometry, in which fluorescein (F) was instilled into one eye and carboxyfluorescein (CF) was instilled into the other eye in a random fashion. The F and CF uptakes were then measured at the central cornea by a slit-lamp fluorophotometer. Three rats from each group were exposed to a horseradish peroxidase (HRP) solution for one hour, and the HRP-reactive substances within the corneal epithelium were also examined via electron microscopy. There was significantly higher F uptake in the galactose group than in the control (p = 0.003) and CT-112 groups (p = 0.028). There were no significant differences in CF uptake between the 3 groups. Histologically, HRP-reactive substances were found in much greater quantities within the superficial corneal cells of the galactose group ...Continue Reading

References

Jun 1, 1979·Archives of Ophthalmology·G N FoulksF I Tolentino
Aug 1, 1978·Archives of Ophthalmology·H D PerryF I Tolentino
Sep 15, 1992·American Journal of Ophthalmology·E K KimH F Edelhauser
Mar 1, 1991·Cornea·K TsubotaJ Shimazaki
Jan 1, 1989·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·M GöbbelsJ Oldendoerp
Mar 15, 1988·American Journal of Ophthalmology·Y OhashiR Manabe
Jul 1, 1988·Medicinal Research Reviews·P F Kador
Sep 1, 1983·American Journal of Ophthalmology·R O SchultzK J Schultz
Jun 1, 1984·Diabetes·Y AkagiJ H Kinoshita
Nov 1, 1980·Experimental Eye Research·S FukushiJ H Kinoshita
Jan 1, 1983·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·P Steuhl, J W Rohen

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Citations

Jun 24, 2008·Journal of Enzyme Inhibition and Medicinal Chemistry·Net Daş-EvcimenRahmiye Ertan
Jul 15, 2015·Retina·Hsi-Fu ChenChi-Chin Sun
May 7, 2009·Acta Ophthalmologica·Saeed AkhtarSaghir Akhtar
Oct 27, 2010·Clinical & Experimental Ophthalmology·Hamdy AbdelkaderRaid G Alany
May 24, 2015·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Hongfei Ye, Yi Lu
Apr 23, 2016·Progress in Retinal and Eye Research·Peter F KadorPeter J Oates
Jul 27, 2001·Progress in Retinal and Eye Research·S KinoshitaK Okubo

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