Effects of alfentanil and lidocaine on the hemodynamic responses to laryngoscopy and tracheal intubation

Journal of Clinical Anesthesia
D PathakR P From

Abstract

This study was undertaken to determine whether lidocaine and/or alfentanil can effectively abolish or attenuate the increase in mean arterial pressure (MAP), heart rate (HR), and rate pressure product (RPP) associated with rapid sequence induction of anesthesia. Sixty patients were randomly divided into four groups. Group 1 received saline 10 ml, group 2 received lidocaine 2 mg/kg, group 3 received alfentanil 15 micrograms/kg, and group 4 received alfentanil 30 micrograms/kg. All patients were induced with sodium thiopental 4 mg/kg and succinylcholine 1.5 mg/kg to facilitate tracheal intubation. The study drug was given after sodium thiopental was administered, and the investigator was blinded to it. Blood pressure (BP) and HR were recorded at the following times: before induction; after induction but before laryngoscopy and intubation; and 1, 3, and 5 minutes after intubation. Alfentanil 15 and 30 micrograms/kg given in rapid sequence fashion with thiopental and succinylcholine effectively blunted the hemodynamic responses to laryngoscopy and tracheal intubation. Lidocaine 2 mg/kg and saline were found to be ineffective in blunting these same responses.

References

Feb 1, 1995·Journal of Clinical Anesthesia·R A VictoryP F White
Jan 3, 2001·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·M A Levitt, G M Dresden
Aug 13, 2010·Acta Anaesthesiologica Scandinavica·A G JensenClinical Practice Committee of the Scandinavian Society of Anaesthesiology and Intensive Care Medicine
Jan 11, 2000·Emergency Medicine Clinics of North America·P S Wadbrook
Jun 1, 1993·Annals of Emergency Medicine·R M Walls
Jul 23, 2015·Iranian Journal of Pediatrics·Mirhadi MussaviMahsa Aminizade

Related Concepts

Arterial Pulse Pressure
Diastolic Blood Pressure
Thiopental Sodium
Trachea
Controlled Clinical Trials, Randomized
Tracheal Diseases
Succinylcholine
Alfentanil hydrochloride
Intubation, Intratracheal
Absence of Sensation

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Synapse Loss as Therapeutic Target in MS

As we age, the number of synapses present in the human brain starts to decline, but in neurodegenerative diseases this occurs at an accelerated rate. In MS, it has been shown that there is a reduction in synaptic density, which presents a potential target for treatment. Here is the latest research on synapse loss as a therapeutic target in MS.

Artificial Intelligence in Cardiac Imaging

Artificial intelligence (ai) techniques are increasingly applied to cardiovascular (cv) medicine in cardiac imaging analysis. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

Social Learning

Social learning involves learning new behaviors through observation, imitation and modeling. Follow this feed to stay up to date on the latest research.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Single Cell Chromatin Profiling

Techniques like ATAC-seq and CUT&Tag have the potential to allow single cell profiling of chromatin accessibility, histones, and TFs. This will provide novel insight into cellular heterogeneity and cell states. Discover the latest research on single cell chromatin profiling here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells.