Effects of alfentanil and lidocaine on the hemodynamic responses to laryngoscopy and tracheal intubation

Journal of Clinical Anesthesia
D PathakR P From


This study was undertaken to determine whether lidocaine and/or alfentanil can effectively abolish or attenuate the increase in mean arterial pressure (MAP), heart rate (HR), and rate pressure product (RPP) associated with rapid sequence induction of anesthesia. Sixty patients were randomly divided into four groups. Group 1 received saline 10 ml, group 2 received lidocaine 2 mg/kg, group 3 received alfentanil 15 micrograms/kg, and group 4 received alfentanil 30 micrograms/kg. All patients were induced with sodium thiopental 4 mg/kg and succinylcholine 1.5 mg/kg to facilitate tracheal intubation. The study drug was given after sodium thiopental was administered, and the investigator was blinded to it. Blood pressure (BP) and HR were recorded at the following times: before induction; after induction but before laryngoscopy and intubation; and 1, 3, and 5 minutes after intubation. Alfentanil 15 and 30 micrograms/kg given in rapid sequence fashion with thiopental and succinylcholine effectively blunted the hemodynamic responses to laryngoscopy and tracheal intubation. Lidocaine 2 mg/kg and saline were found to be ineffective in blunting these same responses.


Feb 1, 1995·Journal of Clinical Anesthesia·R A VictoryP F White
Jan 3, 2001·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·M A Levitt, G M Dresden
Aug 13, 2010·Acta Anaesthesiologica Scandinavica·A G JensenClinical Practice Committee of the Scandinavian Society of Anaesthesiology and Intensive Care Medicine
Jan 11, 2000·Emergency Medicine Clinics of North America·P S Wadbrook
Jun 1, 1993·Annals of Emergency Medicine·R M Walls
Jul 23, 2015·Iranian Journal of Pediatrics·Mirhadi MussaviMahsa Aminizade

Related Concepts

Arterial Pulse Pressure
Diastolic Blood Pressure
Thiopental Sodium
Controlled Clinical Trials, Randomized
Tracheal Diseases
Alfentanil hydrochloride
Intubation, Intratracheal
Absence of Sensation

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