Effects of alkyl parabens on plant pathogenic fungi

Bioorganic & Medicinal Chemistry Letters
Shinsaku ItoShunsuke Yajima

Abstract

Alkyl parabens are used as antimicrobial preservatives in cosmetics, food, and pharmaceutical products. However, the mode of action of these chemicals has not been assessed thoroughly. In this study, we determined the effects of alkyl parabens on plant pathogenic fungi. All the fungi tested, were susceptible to parabens. The effect of linear alkyl parabens on plant pathogenic fungi was related to the length of the alkyl chain. In addition, the antifungal activity was correlated with the paraben-induced inhibition of oxygen consumption. The antifungal activity of linear alkyl parabens likely originates, at least in part, from their ability to inhibit the membrane respiratory chain, especially mitochondrial complex II. Additionally, we determined that some alkyl parabens inhibit Alternaria brassicicola infection of cabbage.

References

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Feb 8, 2011·Journal of Agricultural and Food Chemistry·Tsung-Chun LinJenn-Wen Huang
Mar 13, 2014·Bioorganic & Medicinal Chemistry Letters·Shinsaku ItoShunsuke Yajima

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Citations

Jul 1, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Noureddine HallaMaria Filomena Barreiro
Jul 26, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Dániel NemesIldikó Bácskay
Feb 13, 2018·The Journal of Physical Chemistry. B·Michał FlasińskiPaweł Wydro

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