PMID: 3771852Oct 1, 1986Paper

Effects of all-trans-retinoic acid on the dermis of hairless mice

Journal of the American Academy of Dermatology
L H Kligman

Abstract

The marked degradative changes induced in human and animal dermis by chronic ultraviolet radiation are thought to be irreversible. We have shown in studies with hairless mice that a new normal dermis formed subepidermally after irradiation ceased. Because retinoids stimulate wound repair, we evaluated the ability of all-trans-retinoic acid (RA) to enhance the repair of ultraviolet damage. To produce mild dermal damage, hairless mice were irradiated for 10 weeks with FS20 sunlamps. The mice were then treated topically with various concentrations of RA for either 5 or 10 weeks. The skin was examined by light and electron microscopic techniques. The subepidermal repair zone in RA-treated mice was significantly wider than that in the untreated control group. The greater repair appeared to be retinoid specific and was dose dependent. The collagen was both histochemically and ultrastructurally normal; fibroblasts were numerous and morphologically hyperactive. In addition, topical RA increased dermal vascularity.

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Citations

Jan 1, 1995·Archives of Dermatological Research·G J GendimenicoJ A Mezick
Dec 6, 2006·Archives of Dermatological Research·James VaraniPatricia Perone
Oct 31, 2007·Archives of Dermatological Research·James VaraniRichard A Miller
Mar 1, 1996·Clinics in Dermatology·L H Kligman
Jan 1, 1997·Journal of Photochemistry and Photobiology. B, Biology·B ChaqourA Fourtanier
May 28, 2008·International Journal of Cosmetic Science·K Lintner, O Peschard
Apr 1, 1990·The British Journal of Dermatology·E BerardescaG Rabbiosi
Jul 1, 1991·The British Journal of Dermatology·D W HarrisM H Rustin
Nov 1, 1991·The British Journal of Dermatology·F BernerdJ Czernielewski
Sep 1, 1991·Clinical and Experimental Dermatology·K L Dalziel
Oct 1, 1990·The Journal of Dermatologic Surgery and Oncology·S S Gardner, J S Weiss
Dec 1, 1991·Photochemistry and Photobiology·L H Kligman
May 1, 1992·The Journal of Pharmacy and Pharmacology·K M TramposchR J Bonney
May 1, 1991·Postgraduate Medical Journal·P DiggoryC Weinstein
May 24, 2005·Drugs·Alexander J Stratigos, Andreas D Katsambas
May 1, 1996·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·L S MoyR L Moy
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Oct 1, 1989·Journal of the American Academy of Dermatology·E A OlsenL M Cobo
Sep 1, 1989·Journal of the American Academy of Dermatology·A M Kligman
Oct 21, 2016·Journal of Cutaneous and Aesthetic Surgery·Patrick J Buchanan, Robert H Gilman
Aug 14, 1998·Journal of the American Academy of Dermatology·M L Elson
Feb 1, 1992·Journal of Cutaneous Pathology·S E FligielJ Varani
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Apr 1, 1990·The British Journal of Dermatology·R Marks, L Lever
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Dec 14, 2006·Journal of Cosmetic Dermatology·C RonaE Berardesca
Oct 3, 2009·Archives of Facial Plastic Surgery·Tapan K BhattacharyyaJ Regan Thomas
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May 1, 1989·The American Journal of Medicine·A S Boyd
Dec 1, 1993·The Journal of Investigative Dermatology·J VaraniJ J Voorhees

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