Effects of Allicin on Pathophysiological Mechanisms during the Progression of Nephropathy Associated to Diabetes

Antioxidants
Abraham Said Arellano-BuendíaHoracio Osorio Alonso

Abstract

This study aimed to assess the impact of allicin on the course of diabetic nephropathy. Study groups included control, diabetes, and diabetes-treated rats. Allicin treatment (16 mg/kg day/p.o.) started after 1 month of diabetes onset and was administered for 30 days. In the diabetes group, the systolic blood pressure (SBP) increased, also, the oxidative stress and hypoxia in the kidney cortex were evidenced by alterations in the total antioxidant capacity as well as the expression of nuclear factor (erythroid-derived 2)-like 2/Kelch ECH associating protein 1 (Nrf2/Keap1), hypoxia-inducible factor 1-alpha (HIF-1α), vascular endothelial growth factor (VEGF), erythropoietin (Epo) and its receptor (Epo-R). Moreover, diabetes increased nephrin, and kidney injury molecule-1 (KIM-1) expression that correlated with mesangial matrix, the fibrosis index and with the expression of connective tissue growth factor (CTGF), transforming growth factor-β1 (TGF-β1), and α-smooth muscle actin (α-SMA). The insulin levels and glucose transporter protein type-4 (GLUT4) expression were decreased; otherwise, insulin receptor substrates 1 and 2 (IRS-1 and IRS-2) expression was increased. Allicin increased Nrf2 expression and decreased SBP, Keap1, HIF-1...Continue Reading

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Citations

Jan 29, 2021·Antioxidants·Raelene J Pickering
May 1, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Wamidh H TalibLina T Al Kury
Aug 28, 2021·International Journal of Molecular Sciences·José L Sánchez-GloriaHoracio Osorio-Alonso

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Methods Mentioned

BETA
Enzyme-linked Immunosorbent Assay

Software Mentioned

GraphPad
ImageJ
Axiovision Rel

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