Mar 31, 1976

Effects of allopurinol, propranolol and methylprednisolone on infarct size in experimental myocardial infarction

The American Journal of Cardiology
C H ShatneyR C Lillehei

Abstract

With use of a canine model of occlusion of the left anterior descending coronary artery and an intracellular lactic dehydrogenase stain to measure infarct size directly, the effects of allopurinol, methylprednisolone sodium succinate and propranolol were studied. Allopurinol did not influence the extent of myocardial necrosis, whereas both methylprednisolone and propranolol significantly reduced myocardial infarct size. Possible mechanisms of action and clinical applicability of these agents are discussed.

Mentioned in this Paper

Necrosis
Dioxygen
Myocardium
Myocardial Infarction
Caplenal
Blood
Heart
Hemodynamics
Rexigen
Hydrogen-Ion Concentration

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