PMID: 3758282Oct 1, 1986Paper

Effects of allylglycine on photosensitivity in the lateral geniculate-kindled cat

Experimental Neurology
Y WadaK Yoshida

Abstract

The effects of DL-allylglycine, an inhibitor of GABA synthesis, on the responses to photic stimulation were studied in the cat kindled in the lateral geniculate body (GL). For 3 to 8 h after the injection of DL-allylglycine at a subconvulsant dose (30 or 40 mg/kg, i.v.), the kindled cat showed a stable level of photosensitivity without any toxic effects and responded with various degrees of myoclonus or a generalized tonic-clonic convulsion when photic stimulation was repeated at hourly intervals. The incidence of photically induced myoclonus reached its plateau during this period. Our results suggest that photosensitivity of the lateral geniculate-kindled cat is related to the modification of GABAergic mechanisms, and that when the GL-kindled cat is pretreated with DL-allylglycine it is a reliable model of photosensitive epilepsy.

References

May 15, 1978·Biochemical Pharmacology·R W Horton
Oct 1, 1979·Electroencephalography and Clinical Neurophysiology·B S MeldrumJ M Stutzmann
Jan 1, 1975·International Review of Neurobiology·B S Meldrum
May 1, 1975·Archives of Neurology·B S MeldrumP A Toseland
Feb 1, 1986·Experimental Neurology·Y WadaN Yamaguchi
Nov 1, 1971·Electroencephalography and Clinical Neurophysiology·J YamamotoY Hishikawa
Sep 1, 1971·The International Journal of Neuroscience· Rodríguez de Lores ArnE De Robertis
Feb 28, 1973·Brain Research·S HansenM Sokol
Jan 1, 1972·Experimental Brain Research·D R Curtis, A K Terbécis
Aug 1, 1965·Life Sciences·D McFarland, A Wainer
Nov 1, 1969·Experimental Neurology·G V GoddardC K Leech
Aug 15, 1980·The Journal of Comparative Neurology·P Sterling, T L Davis
Jan 1, 1954·Journal of Neurosurgery·J HANBERY, H JASPER
Jan 1, 1965·Experimental Neurology·J T WALSH, J P CORDEAU

❮ Previous
Next ❯

Citations

Jun 1, 1988·The Japanese Journal of Psychiatry and Neurology·Y WadaN Yamaguchi
Jun 1, 1990·The Japanese Journal of Psychiatry and Neurology·Y Wada, N Yamaguchi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Amygdala and Midbrain Dopamine

The midbrain dopamine system is widely studied for its involvement in emotional and motivational behavior. Some of these neurons receive information from the amygdala and project throughout the cortex. When the circuit and transmission of dopamine is disrupted symptoms may present. Here is the latest research on the amygdala and midbrain dopamine.

Amygdala: Sensory Processes

Amygdalae, nuclei clusters located in the temporal lobe of the brain, play a role in memory, emotional responses, and decision-making. Here is the latest research on sensory processes in the amygdala.