Effects of Aloe barbadensis Mill. extract (AVH200®) on human blood T cell activity in vitro

Journal of Ethnopharmacology
Bani AhluwaliaL Ohman

Abstract

Aloe barbadensis Mill. (Aloe vera) is a widely used medicinal plant well reputed for its diverse therapeutic applications. It has been used for thousands of years in folk medicine to treat various conditions and the Aloe vera gel has been reported to possess anti-inflammatory as well as immunostimulatory and immunomodulatory properties. However, the mode of action is still unclear. The aim of this study was determine the effects of two well-defined A. barbadensis Mill. extracts AVH200® and AVE200 on human blood T cells in vitro. Peripheral blood mononuclear cells (PBMC) from healthy donors were stimulated polyclonally in the presence or absence of AVH200® and AVE200. The T cell phenotype was investigated by flow cytometry, cell proliferation was determined by CFSE dye and thymidine assay, respectively and cytokine secretion was determined by MSD® Multi-Spot Assay system and ELISA. The presence of AVH200® resulted in a reduced expression of CD25 among CD3(+) T cells and suppression of T cell proliferation in a dose dependent manner. Furthermore, AVH200® reduced the expression of CD28 on CD3(+) T cells. AVH200® also reduced the secretion of IL-2, IFN-γ and IL-17A in PBMC cultures. The AVH200® dose dependent reduction in T cell ac...Continue Reading

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Citations

Dec 28, 2017·International Journal of Experimental Pathology·Tao ChenChunyan Hu
Mar 19, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Marta SánchezM Pilar Gómez-Serranillos
Jul 23, 2020·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Eirini Dimidi, Kevin Whelan
Apr 4, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Zaira LópezPeter Knauth
Apr 22, 2020·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Bani AhluwaliaLena Öhman
Jun 23, 2018·Nature Reviews. Gastroenterology & Hepatology·Magnus Simrén, Jan Tack

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