Effects of alpha 1-adrenergic receptor subtype selective antagonists on lower urinary tract function in rats with bladder outlet obstruction

The Journal of Urology
Baojun GuPaul C Dolber

Abstract

Antagonists of alpha 1-adrenergic receptors (alpha 1ARs) relieve obstructive and irritative symptoms in patients with bladder outlet obstruction. However, to our knowledge mechanisms underlying the relief of irritative symptoms remain unknown. Because bladder alpha 1dARs are up-regulated in some rats with bladder outlet obstruction, we investigated the effect of the alpha 1aAR antagonist 5-methyl urapidil (5MU) vs the alpha 1a/alpha 1dAR antagonist tamsulosin on urinary frequency in obstructed rats. Baseline frequency was measured using a chronic micturition recording system and then obstruction (40 rats) or sham obstruction surgery (11 rats) was performed. After 6 weeks frequency was reassessed, followed by subcutaneous implantation of osmotic pumps to deliver 5MU, tamsulosin or vehicle for 1 week. Upon the completion of drug treatment urinary frequency was again measured and the pressor response to the alpha 1AR agonist phenylephrine was documented. Obstructed bladder mass was an average of 4.9 times greater than bladder mass in sham operated rats (p <0.001). Urinary frequency was elevated in obstructed rats with a bladder mass of greater than 500 mg vs all rats with a bladder mass of under 255 mg (p = 0.01). Of rats with a b...Continue Reading

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Citations

Mar 16, 2011·International Journal of General Medicine·Sakineh HajebrahimiHomayoun Sadeghi-Bazargani
Apr 20, 2014·Indian Journal of Urology : IJU : Journal of the Urological Society of India·Martin HennenbergChristian Gratzke
Dec 2, 2008·European Journal of Pharmacology·Michela BuccioniGabriella Marucci
Jan 29, 2008·Pharmacology & Therapeutics·Martin C Michel, Maurits M Barendrecht
Jan 4, 2007·Autonomic & Autacoid Pharmacology·M M BarendrechtR M Levin
Feb 9, 2006·British Journal of Pharmacology·Martin C Michel, Wim Vrydag
Dec 17, 2014·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Osman Raif KarabacakMurat Alper
Feb 2, 2006·International Journal of Urology : Official Journal of the Japanese Urological Association·Satoru TakahashiTadaichi Kitamura
Jan 31, 2012·Urologia·Emilio Sacco
Sep 17, 2013·Neurourology and Urodynamics·Martin HennenbergChristian Gratzke
Dec 5, 2012·International Journal of Urology : Official Journal of the Japanese Urological Association·Osamu IshizukaKarl-Erik Andersson
Nov 17, 2004·Mayo Clinic Proceedings·Debra A SchwinnPerinchery Narayan
Nov 28, 2009·The Urologic Clinics of North America·Gregory B AuffenbergKevin T McVary

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