PMID: 2877699Oct 1, 1986

Effects of alpha-adrenoceptor agonists and antagonists on ouabain-induced arrhythmias and cardiac arrest in guinea-pig

British Journal of Pharmacology
G P Thomas, R M Tripathi

Abstract

Effects of alpha-adrenoceptor agonists and antagonists with different affinity for alpha 1- and alpha 2-receptors on ouabain-induced arrhythmias in guinea-pigs were studied. Early arrhythmias, ventricular fibrillation and cardiac arrest were induced in anaesthetized guinea-pigs by the slow intravenous infusion of ouabain. Phenylephrine and yohimbine potentiated the cardiotoxicity of ouabain significantly whereas prazosin and clonidine showed significant antiarrhythmic effects and delayed the cardiac arrest. It is concluded that selective alpha 1-receptor stimulation and alpha 2-receptor blockade increases the cardiotoxic effects of ouabain and selective alpha 2-receptor stimulation and alpha 1-receptor blockade inhibits ouabain-induced arrhythmias and cardiac arrest in guinea-pigs.

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Citations

Dec 1, 1991·Cardiovascular Drugs and Therapy·N NoguchiH Mashiba
Dec 4, 1990·European Journal of Pharmacology·J HasegawaH Mashiba
Jan 1, 1991·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·H KotakeH Mashiba
Jun 18, 2005·Journal of Pharmacological and Toxicological Methods·Daniela S HauserGuido Hanauer
Dec 1, 1988·Journal of the American College of Cardiology·J HasegawaH Mashiba
Apr 1, 1995·Journal of Autonomic Pharmacology·G P Thomas
Dec 1, 1991·British Journal of Pharmacology·G P Thomas, P M Stephen
Apr 1, 1988·British Journal of Pharmacology·R M Tripathi, R Kaushal
Mar 11, 2005·Autonomic & Autacoid Pharmacology·A T Demiryürek, S Demiryürek

Related Concepts

Adrenergic alpha-Agonists
Adrenergic alpha-Antagonists
Cardiac Depressants
Cardiac Arrhythmia
Diastolic Blood Pressure
Drug Interactions
Cavia porcellus
Cardiac Arrest
Pulse Rate
Ouabain

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