PMID: 6110792Aug 1, 1980Paper

Effects of alpha blockers on blood pressure and on the Ca-contracture of cat aortic strips

Japanese Journal of Pharmacology
K Hoshi, S Fujino

Abstract

To further clarify the hypotensive mechanism of adrenergic alpha blockers, effects of several alpha blockers on systemic blood pressure and on Ca-contracture of isolated, cat aortic strips were studied. For this purpose, the effects of known adrenergic alpha blockers, phentolamine, phenoxybenzamine, and a newly synthesized adrenergic alpha blocker (2-(N-(n-Butyloyl)homopiperazine-N'-yl)-4-amino-6,7-dimethoxy quinazoline; E-643) were compared with those of nitroglycerin and verapamil. Systemic blood pressure was decreased by administration (2 x 10(-8) moles/kg i.v.) of all drugs except phenoxybenzamine. The order of maximal fall of diastolic blood pressure after the injection was; nitroglycerin greater than E-643 greater than phentolamine greater than verapamil greater than phenoxybenzamine. Although "adrenaline reversal" was observed after 2 x 10(-7) moles/kg of phenoxybenzamine, i.e. a 10-fold increase in the dose of phenoxybenzamine, there was no decrease in systemic blood pressure with this dose. All these drugs in a concentration of 2 x 10(-6) M inhibited the Ca-contracture (phasic and tonic) of the depolarized aortic strips. The order of inhibition of phasic and tonic contracture was: nitroglycerin greater than E-643, vera...Continue Reading

Citations

Feb 1, 1989·The American Review of Respiratory Disease·P BoschettoP J Barnes
Aug 1, 1991·Naunyn-Schmiedeberg's Archives of Pharmacology·A M ZhangB M Altura
Jan 1, 1986·Clinical and Experimental Hypertension. Part A, Theory and Practice·M NakaiY Matsui
Sep 1, 1982·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·C YamatoT Fujita
Feb 15, 1988·Biochemical and Biophysical Research Communications·H OrimoY Ouchi

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