Jul 1, 1992

Effects of alpha-interferon on the level of adenosine metabolism enzymes and bactericidal activity of macrophages in staphylococcal infection

Biulleten' eksperimental'noĭ biologii i meditsiny
L N LazarenkoV K Ivanenko

Abstract

In staphylococcal infection the changes in functional ability of macrophages occur: their oxygen-depending bactericidity and adenosine-desaminase activity are depressed 5-nucleotidase ability increases. Introduction of homologous alpha-IFN in the dose of 1 x 10(3) u/mouse leads to enhancing macrophage bactericidity of the animals infected, inhibits their 5-nucleotidase activity and enhances adenosine desaminase one. Influence of alpha-IFN on the activity of adenosine metabolism enzymes in macrophages can be considered one of the most important mechanisms of its modulating effect in bacterial infections.

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Mentioned in this Paper

Mice, Inbred CBA
Adenosine
Enzymes, antithrombotic
Depressed - Symptom
Staphylococcal Infections
Bactericidal Activity
Interferon alpha-1
IFNA1 gene
Enzymes for Treatment of Wounds and Ulcers
Macrophage

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