Effects of Alpha-Lipoic Acid Supplementation on Inflammatory Biomarkers and Matrix Metalloproteinase-3 in Rheumatoid Arthritis Patients

Journal of the American College of Nutrition
Elham MirtaheriMehran Mesgari Abbasi

Abstract

Although many studies have considered alpha-lipoic acid (ALA) as a potent antioxidant with anti-inflammatory functions in oxidative stress-associated inflammatory diseases, few studies have evaluated its efficacy in rheumatoid arthritis (RA). Therefore, we aimed to examine the effects of ALA on serum biomarkers of joint damage and inflammation in women with RA. We performed a randomized, double-blind, placebo-controlled clinical trial in which RA patients (n = 70) aged 20-50 years were randomly assigned 1:1 to receive either ALA (1200 mg/day) or placebo for 8 weeks. Fasting blood samples were taken before and after the study to analyze inflammatory biomarkers including serum high-sensitivity C-reactive protein (hs-CRP), tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), and serum matrix metalloproteinase-3 (MMP-3) as a marker of joint erosion. Moreover, 3-day dietary records, the International Physical Activity Questionnaire (IPAQ), and the Spielberger State-Trait anxiety inventory form Y (STAI-Y) were assessed before and after the intervention. Sixty-five RA patients completed the trial. No statistically significant differences were observed in serum levels of hs-CRP, TNF-α, IL-6, and MMP-3 within and between the ALA a...Continue Reading

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Citations

Jun 4, 2008·Best Practice & Research. Clinical Rheumatology·Margaret P Rayman, Dorothy J Pattison
Jun 26, 2020·Nutrition Reviews·Elena PhilippouElena Nikiphorou
Feb 23, 2019·International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition·Sousan KolahiMehran Mesgari Abbasi
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Jun 2, 2021·Auto- Immunity Highlights·Yolima Puentes-OsorioDaniel Taborda

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay
biopsies

Software Mentioned

SPSS
Nutritionist

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