PMID: 2503670Jan 1, 1989Paper

Effects of alprazolam and clonidine on carbon dioxide-induced increases in anxiety ratings in healthy human subjects

Life Sciences
S W WoodsD S Charney

Abstract

In order to investigate possible neurobiologic mechanisms underlying carbon dioxide-induced anxiety, the effects of oral alprazolam 0.75 mg and intravenous clonidine 2 mcg/kg on CO2-induced increases in ratings of subjective anxiety, pulse rate, and ventilation were measured in healthy human subjects. Pretreatment with alprazolam but not with clonidine significantly reduced the CO2-induced increase in ratings of anxiety. Neither drug altered CO2-induced increases in pulse rate or ventilatory responses. Clonidine did produce potent sedative and hypotensive effects. The behavioral data suggest that the mechanisms through which CO2 induces anxiety-like effects involve neural systems regulated by benzodiazepine receptors and, secondly, that they appear not to require normal functioning of noradrenergic systems. Carbon dioxide may provide a useful model system for identification of new drugs with anxiolytic properties.

References

Dec 1, 1977·Naunyn-Schmiedeberg's Archives of Pharmacology·J Garcia de Yebenes ProusM A Mena Gomez
May 1, 1984·The British Journal of Psychiatry : the Journal of Mental Science·M A Van den Hout, E Griez
Nov 1, 1981·Archives of General Psychiatry·R Hoehn-SaricV K Smith

❮ Previous
Next ❯

Citations

Jan 1, 1990·Pharmacology & Therapeutics·D J Nutt
Aug 19, 2008·Respiratory Physiology & Neurobiology·Antonio E NardiWalter A Zin
May 20, 2008·Pharmacology, Biochemistry, and Behavior·Jayne E Bailey, David J Nutt
Aug 19, 2014·Neuroscience and Biobehavioral Reviews·Philip L JohnsonAnantha Shekhar
Oct 11, 2013·Journal of Psychopharmacology·Stefano Zanone PomaStefano Milleri
Sep 17, 2005·Journal of Psychopharmacology·Stefano Zanone PomaEmilio Merlo-Pich
Mar 15, 2006·Journal of Psychopharmacology·Jayne E BaileyDavid J Nutt
Feb 1, 1992·The British Journal of Psychiatry : the Journal of Mental Science·D Nutt, C Lawson
Sep 30, 2003·Journal of Psychopharmacology·J E BaileyD J Nutt

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.