Effects of alprazolam on intravenous cocaine self-administration in rats

Pharmacology, Biochemistry, and Behavior
Nick E GoedersG F Guerin

Abstract

The specificity of benzodiazepine pretreatment on the reinforcing efficacy of cocaine was investigated using a multiple schedule of cocaine and food presentation. Cocaine was available under a fixed-ratio 4 schedule of reinforcement during 1 h of the session, while food was delivered under a discrete-trial, fixed-ratio 10 schedule during the other. Following initial exposure to alprazolam, responding maintained by both cocaine and food was significantly reduced. However, tolerance quickly developed to the sedative effects of alprazolam on food-maintained responding, while no reduction in the effects of the drug on cocaine self-administration was observed. Alprazolam (0.5 to 4.0 mg/kg, IP) significantly reduced cocaine intake without affecting food-maintained responding following subsequent testing with the drug. These data suggest a potential specific effect (e.g., anxiolytic) of alprazolam in cocaine reinforcement.

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Citations

Dec 4, 2003·Pharmacology, Biochemistry, and Behavior·Jamie L HagaCraig R Rush
Sep 19, 2003·Pharmacology, Biochemistry, and Behavior·William L Woolverton
May 1, 1997·Pharmacology, Biochemistry, and Behavior·N E GoedersG F Guerin
Feb 11, 1999·Pharmacology, Biochemistry, and Behavior·E MeririnneT Seppälä
Dec 26, 2001·Psychoneuroendocrinology·Nick E Goeders
May 1, 1997·Psychoneuroendocrinology·N E Goeders
Aug 10, 2000·Drug and Alcohol Dependence·N E GoedersG F Guerin
Jul 29, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Nancy K MelloJack H Mendelson
Oct 1, 2011·Addiction Biology·Eric AugierSerge H Ahmed
Apr 9, 1999·Alcoholism, Clinical and Experimental Research·C L CzachowskiC E Denning
Jul 22, 2005·The Journal of Pharmacology and Experimental Therapeutics·Andrew C BarrettS Barak Caine
Feb 4, 2012·Future Medicinal Chemistry·Craig R Rush, William W Stoops
Jun 3, 2014·Brain Research·Glenn F GuerinNicholas E Goeders
Apr 15, 2014·Perceptual and Motor Skills·Nadav GoldschmiedJason Kowalczyk
Dec 5, 2008·Drug and Alcohol Dependence·W L Woolverton, Zhixia Wang
Jun 24, 2004·European Journal of Pharmacology·Maciej GasiorPatrik Munzar
May 26, 2004·Pharmacology, Biochemistry, and Behavior·James E Goeders, Nick E Goeders
Jun 17, 2006·European Journal of Pharmacology·Małgorzata FilipEdmund Przegaliński
Sep 27, 2005·Pharmacology, Biochemistry, and Behavior·Joshua A LileCraig R Rush
Jul 12, 2005·Drug and Alcohol Dependence·Elise M WeertsRoland R Griffiths
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Jul 27, 2000·Annals of the New York Academy of Sciences·D C Roberts, K Brebner

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