Effects of altered maternal folate and vitamin B12 on neurobehavioral outcomes in F1 male mice

Brain Research Bulletin
Mohit KumarRajat Sandhir

Abstract

Maternal folate and vitamin B12 status during pregnancy may influence development of central nervous system (CNS) in the offspring. Very little attention has been paid to understand the combined effects of both the vitamins during pregnancy. The present study was designed to evaluate the biochemical and behavioral outcomes following alterations in folate and vitamin B12 levels in C57BL/6 mice. The female mice were fed with different combinations of folate and vitamin B12 whereas; males were fed with normal diet for 4 weeks. The mice were mated and the pregnant mice received the same diets as before pregnancy. The F1 male mice were further continued on maternal diet for 6 weeks following neurobehavioral and biochemical assessment. The body weight of the F1 male mice was significantly decreased in the mice that received folate and vitamin B12 deficient diet. Altered cognitive functions were observed in the folate and B12 deficient F1 male mice as assessed by Morris water maze and novel object recognition tests. Spontaneous locomotor activity was decreased in F1 male mice fed with folate and B12 deficient diets. Elevated homocysteine levels and decreased hydrogen sulfide levels were also observed in the brain of F1 male mice on fo...Continue Reading

References

May 1, 1984·Journal of Neuroscience Methods·R Morris
Dec 1, 1996·Nutrition Reviews·T Bottiglieri
Oct 9, 1998·Journal of Neuroscience Methods·G RozasJ L Labandeira-García
Jun 22, 2002·BMJ : British Medical Journal·E H Reynolds
Jul 11, 2003·Vitamins and Hormones·Larry H Matherly, David I Goldman
Jan 28, 2006·Stroke; a Journal of Cerebral Circulation·Kun QuPeter T-H Wong
Feb 24, 2007·Toxicology Letters·Neus Franco-PonsElisabet Vilella
Feb 1, 2008·The Proceedings of the Nutrition Society·Robert Clarke
Oct 4, 2008·European Journal of Nutrition·David Benton, UNKNOWN ILSI Europe a.i.s.b.l
Aug 20, 2008·Food and Nutrition Bulletin·Maureen M Black
Aug 20, 2008·Proceedings of the National Academy of Sciences of the United States of America·Aron M TroenIrwin H Rosenberg
May 26, 2011·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Madhavi Dhobale, Sadhana Joshi
Jun 5, 2012·Journal of Zhejiang University. Science. B·Tóshiko Takahashi-IñiguezMaría Elena Flores
Mar 12, 2013·Trends in Endocrinology and Metabolism : TEM·Jean-Louis GuéantJean-Luc Daval
Apr 24, 2013·Journal of Inherited Metabolic Disease·N Joan Abbott
Feb 28, 2014·Cardiovascular Therapeutics·Balazs Debreceni, Laszlo Debreceni
Aug 3, 2014·Molecular Neurobiology·Shashi Kant TiwariRajnish Kumar Chaturvedi
Nov 6, 2014·The Proceedings of the Nutrition Society·C McGarelH McNulty
Sep 18, 2015·Fundamental & Clinical Pharmacology·Pankaj Bhatia, Nirmal Singh
Dec 6, 2016·Nutrients·Gianluca RizzoSalvatore Giovanni Vitale
Apr 6, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·John I Toohey
Jun 6, 2018·CNS & Neurological Disorders Drug Targets·Mohit Kumar, Rajat Sandhir

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