Effects of aluminum adjuvant on systemic reactions of lipopolysaccharides in swine

Vaccine
M NorimatsuY Tamura

Abstract

In vivo effects of aluminum adjuvant on systemic reaction of bacterial lipopolysaccharide (LPS) in piglets were investigated. Intramuscular injection of 0.1 mg kg-1 of LPS added to aluminum hydroxide gel (LPS(+)AL) mitigated the leukopenia, trembling and serum levels of TNF-alpha and cortisol compared with the injection of LPS suspended in LPS-free saline (LPS(+)SALINE). The serum endotoxin levels were reduced remarkably but relatively long-lasting in the LPS(+)AL. The lethality in mice injected with LPS added to aluminum hydroxide gel was significantly reduced. Likewise, the Limulus activity of a test LPS was reduced by the addition of aluminum hydroxide gel or aluminum chloride.

Citations

Dec 20, 2002·Journal of Veterinary Medicine. B, Infectious Diseases and Veterinary Public Health·G MüllerH Köhler
Dec 22, 2007·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Daniel KrewskiVirginie Rondeau
Oct 14, 2004·Immunology and Cell Biology·Erik B Lindblad
Apr 10, 2002·American Journal of Veterinary Research·Harm HogenEschDouglas J DeBoer
Feb 19, 2015·Human Vaccines & Immunotherapeutics·Peng HeZhongyu Hu
Sep 30, 2004·Biologicals : Journal of the International Association of Biological Standardization·Yasuaki OgikuboYutaka Tamura
Jul 9, 2008·Drug Development and Industrial Pharmacy·Subrata MallickGaurisankar Ghoshal
May 27, 2005·Vaccine·S ValtuliniH Morvan
Aug 28, 2018·Human Vaccines & Immunotherapeutics·Dan ZhengZe Chen

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