Effects of aluminum on phosphate metabolism in rats: a possible interaction with vitamin D3 renal production

Archives of Toxicology
Stella T MahieuMaría Mónica Elías

Abstract

The effect of chronic aluminum (Al) administration on the phosphorous (Pi) metabolism of different target tissues was studied. Male Wistar rats received aluminum lactate for 3 months (5.75 mg/kg bodyweight of Al, i.p., three times per week). The animals were studied at the end of the 1st, 2nd and 3rd month of treatment. They were housed individually in metabolic cages for 4 days to study Pi and calcium (Ca) balance. Daily food and water intakes were recorded for all animals and urine and feces were collected for Pi and calcium assays. After 3 months the Pi intestinal absorption and the Pi deposition in bone were studied using 32Pi. Another group of rats was treated daily for 7 days with calcitriol (0.08 microg/kg body weight in sesame oil, i.p.) and the Pi balance was studied for the last 4 days. The results indicated that chronic administration of Al affected simultaneously the Pi and calcium balance, with a significant diminution of calcium and increased Pi accretion in bones, together with a diminution in the intestinal absorption of Pi. The treatment of the rats with calcitriol promoted a normalized Pi balance in Al treated rats. These findings suggest that Al could modify the Pi metabolism acting directly on intestine, kid...Continue Reading

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Citations

Oct 5, 2010·Biological Trace Element Research·Xinwei LiZhigang Zhang
May 4, 2011·Biological Trace Element Research·María del Carmen ContiniStella Mahieu
Dec 22, 2007·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Daniel KrewskiVirginie Rondeau
Jun 23, 2009·Toxicology Letters·Stella MahieuNéstor Millen
Oct 18, 2015·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Xudong SunWannan Liang
Jan 21, 2009·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Rim KarboujP Nortier
May 9, 2014·Journal of Occupational and Environmental Medicine·Theodore I Lidsky
Mar 29, 2018·Biological Trace Element Research·Xi WeiBiaoliang Wu

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