Effects of ambient hydrostatic pressure on the material properties of the encapsulation of an ultrasound contrast microbubble

The Journal of the Acoustical Society of America
Krishna N Kumar, Kausik Sarkar

Abstract

Ultrasound contrast microbubbles experience widely varying ambient blood pressure in different organs, which can also change due to diseases. Pressure change can alter the material properties of the encapsulation of these microbubbles. Here the characteristic rheological parameters of contrast agent Definity are determined by varying the ambient pressure (in a physiologically relevant range 0-200 mm Hg). Four different interfacial rheological models are used to characterize the microbubbles. Effects of gas diffusion under excess ambient pressure are investigated in detail accounting for size decrease of contrast microbubbles. Definity contrast agent show a change in their interfacial dilatational viscosity (3.6 × 10(-8) Ns/m at 0 mm Hg to 4.45 × 10(-8) Ns/m at 200 mm Hg) and interfacial dilatational elasticity (0.86 N/m at 0 mm Hg to 1.06 N/m at 200 mm Hg) with ambient pressure increase. The increase results from material consolidation, similar to such enhancement in bulk properties under pressure. The model that accounts for enhancement in material properties with increasing ambient pressure matches with experimentally measured subharmonic response as a function of ambient pressure, while assuming constant material parameters ...Continue Reading

References

May 13, 1999·Ultrasound in Medicine & Biology·W T ShiB B Goldberg
Sep 15, 1999·Ultrasonic Imaging·W T ShiB B Goldberg
May 2, 2000·The Journal of the Acoustical Society of America·L HoffJ M Hovem
Dec 31, 2003·Ultrasound in Medicine & Biology·Dhiman Chatterjee, Kausik Sarkar
May 4, 2005·Ultrasound in Medicine & Biology·Dan AdamElina Burla
Jun 7, 2005·Ultrasound in Medicine & Biology·Dhiman ChatterjeeNathan E Schreppler
Aug 3, 2005·IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control·Flemming ForsbergBarry B Goldberg
May 25, 2007·Ultrasound in Medicine & Biology·David E GoertzAntonius F W van der Steen
Jun 8, 2007·The Journal of the Acoustical Society of America·Alexander A Doinikov, Paul A Dayton
Jun 10, 2008·The Journal of the Acoustical Society of America·Kostas Tsiglifis, Nikos A Pelekasis
Jun 16, 2009·Journal of Colloid and Interface Science·Amit KatiyarPankaj Jain
Jul 9, 2009·Journal of the American College of Cardiology·Gérald SimonneauRogério Souza
Jul 21, 2009·Ultrasound in Medicine & Biology·Kausik SarkarPankaj Jain
Oct 14, 2009·Ultrasonics·Klaus Scheldrup Andersen, Jørgen Arendt Jensen
Dec 17, 2009·Journal of Colloid and Interface Science·Amit Katiyar, Kausik Sarkar
Aug 14, 2010·IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control·Peter J A FrinkingMarcel Arditi
Jan 25, 2011·Ultrasound in Medicine & Biology·Telli FaezNico De Jong
Apr 12, 2011·The Journal of the Acoustical Society of America·Amit KatiyarFlemming Forsberg
Nov 18, 2011·The Journal of the Acoustical Society of America·Amit Katiyar, Kausik Sarkar
Apr 17, 2012·Ultrasound in Medicine & Biology·Brandon L HelfieldDavid E Goertz
Nov 14, 2012·The Journal of the Acoustical Society of America·Amit Katiyar, Kausik Sarkar
Feb 12, 2013·Biomacromolecules·Rahul NahireSanku Mallik
Nov 23, 2013·Ultrasound in Medicine & Biology·Jason L RaymondChristy K Holland

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Citations

Jan 19, 2016·Ultrasound in Medicine & Biology·Krishna N Kumar, Kausik Sarkar
Oct 9, 2016·Ultrasound in Medicine & Biology·Siyu LiuDong Zhang
May 22, 2016·Biomedical Microdevices·Madhuvanthi A KandadaiChristy K Holland
Nov 28, 2017·Ultrasound in Medicine & Biology·Himanshu ShekharChristy K Holland

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