Effects of amifostine on healing of microvascular anastomoses, flap survival, and nerve regeneration with preoperative or postoperative irradiation

Microsurgery
Atakan AydinSeyhun Solakoğlu

Abstract

Amifostine is an organic thiophosphate compound, which has both cytoprotective and radioprotective effects. An experimental study was undertaken to investigate the effects of its use on reconstructive surgery in cancer treatment. One hundred and twenty guinea pigs were divided into three equal groups to investigate flap survival and healing, patency of microvascular anastomoses, and nerve regeneration, respectively. The groups were subdivided in such a way that they were given either preoperative or postoperative radiotherapy, with or without amifostine treatment. Macroscopic and planimetric examination, light and electron microscopy, and histomorphometric analyses were performed to evaluate flap survival and healing, patency of arterial anastomoses, and nerve regeneration. Although flap survival rates were not affected, significantly better flap healing was observed in the postoperative radiotherapy subgroup with amifostine treatment. However, amifostine treatment did not result in a statistically significant difference in terms of anastomotic patency and nerve regeneration with either preoperative or postoperative radiotherapy.

References

Apr 1, 1978·British Journal of Plastic Surgery·E TanM Brennen
Apr 1, 1979·British Journal of Plastic Surgery·B L Cunningham, A R Shons
Apr 1, 1979·The Journal of Surgical Research·K K ThakralT K Hunt
Feb 1, 1978·Archives of Otolaryngology·S R BakerW R Panje
Oct 1, 1977·Nature·P J PolveriniE R Unanue
Dec 1, 1992·American Journal of Surgery·K AitasaloE Virolainen
Jan 1, 1985·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·P M Calabro-JonesJ F Ward
May 1, 1986·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·A RojasJ Denekamp
May 1, 1980·British Journal of Cancer·J M Yuhas
Jul 1, 1982·British Journal of Plastic Surgery·C KragS H Shapiro
Apr 30, 1993·International Journal of Radiation Oncology, Biology, Physics·L J PetersR A Frankenthaler
Feb 1, 1997·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·S KurulE Darendeliler
Mar 5, 1998·International Journal of Radiation Oncology, Biology, Physics·R E LundahlK D Olsen
Apr 2, 1998·Annals of Plastic Surgery·K BrandtD Cromeens
Sep 10, 1999·Journal of Reconstructive Microsurgery·K BrandtC Patrick
Jan 7, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·W M MendenhallN J Cassisi
Oct 3, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·D M BrizelR Sauer
Nov 18, 2000·Journal of Reconstructive Microsurgery·A ArinciM Erer
Feb 24, 2001·Drug Metabolism and Drug Interactions·D J GrdinaJ S Murley
Dec 13, 2002·Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery·Petri Virolainen, Kalle Aitasalo
Feb 13, 2003·American Journal of Otolaryngology·William M MendenhallDietmar W Siemann
Mar 26, 2003·International Journal of Oral and Maxillofacial Surgery·Z WangW M Mendenhall
Apr 25, 2003·Plastic and Reconstructive Surgery·Gregory R D Evans, Keith Brandt

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