Effects of aminotriazole on ethanol, water, and food intake and on brain catalase in UChA and UChB rats

Alcohol
L TampierJ Mardones

Abstract

Aminotriazole (AT), a catalase inhibitor, was administered to UChA (low ethanol consumer) and UChB (high ethanol consumer) rats. Ethanol, water, and solid food intake were measured during basic, treatment, and posttreatment periods. The effects of AT on brain catalase activity and acetaldehyde recovered during incubation of brain homogenates with ethanol were also studied in rats of both strains. Results showed that AT decreased voluntary ethanol intake in UChB rats, and also diminished the consumption of food by rats of both strains. No strain difference in brain catalase activity and acetaldehyde recovered during ethanol incubation was observed. The results suggest that AT effect on ethanol consumption is secondary to a reduction in the appetite for calories and not related to its catalase blocking effect.

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Citations

Apr 12, 2003·Drug and Alcohol Dependence·Etienne QuertemontPhilippe De Witte
Sep 16, 1999·Alcohol·Carla Sanchis-SeguraC M Aragon
Dec 1, 1999·Comparative Biochemistry and Physiology. Part C, Pharmacology, Toxicology & Endocrinology·M J HuentelmanP Johnson
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Mar 27, 2013·Alcoholism, Clinical and Experimental Research·Lutske TampierYedy Israel
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Sep 17, 2013·Alcoholism, Clinical and Experimental Research·Juan Carlos LedesmaCarlos M G Aragon
Apr 2, 2015·Alcoholism, Clinical and Experimental Research·Yedy IsraelMario Herrera-Marschitz
Aug 28, 2020·Frontiers in Behavioral Neuroscience·María Elena QuintanillaYedy Israel
Feb 25, 2017·Frontiers in Behavioral Neuroscience·Anna BrancatoCarla Cannizzaro
Nov 29, 2016·Journal of Experimental Neuroscience·Alessandra T PeanaElio Acquas

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