Effects of amiodarone on thyroid function in patients with ischaemic heart disease.

British Heart Journal
D A PritchardP J Hurley

Abstract

Thyroid function was evaluated clinically and biochemically in 12 patients with ischaemic heart disease receiving 200 mg oral amiodarone three times daily for periods up to 6 weeks. During drug administration, no patient developed clinical or laboratory evidence of hypothyroidism, but serum levels of T3 tended to fall and those of T4 increased but not to levels outside the normal range. Amiodarone produced a significant reduction in heart rate with prolongation of the QTc interval of the electrocardiogram without altering either the PR interval or the QRS duration. These effects of the drug were still present 4 weeks after cessation of treatment. In spite of the high iodine content, amiodarone does not, therefore, depress thyroid function to any important degree during chronic administration and its antianginal action does not appear to be caused by the production of generalized hypothyroidism.

Citations

Jan 1, 1983·European Journal of Clinical Pharmacology·J MoreraJ R Laporte
Jan 1, 1987·European Journal of Clinical Pharmacology·C D BurgessT J Maling
Jun 27, 1980·European Journal of Pharmacology·P TouboulG Kirkorian
Jan 1, 1982·Pharmacology & Therapeutics·R S Bexton, A J Camm
Aug 29, 1996·The American Journal of Cardiology·B N Singh
Apr 1, 1984·Journal of the American College of Cardiology·D P ZipesJ J Heger
Aug 13, 1999·Journal of Cardiovascular Pharmacology·S Shahrara, V Drvota
Jan 25, 1986·British Medical Journal·E MonteiroC Ribeiro
Jan 1, 1979·British Heart Journal·A WaleffeH E Kulbertus
Nov 1, 1979·British Heart Journal·P TouboulG Kirkorian
Jan 1, 1979·Postgraduate Medical Journal·P J WheelerD A Chamberlain
May 1, 1980·Postgraduate Medical Journal·S KeidarA Palant
Nov 1, 1982·Postgraduate Medical Journal·N S JaggaraoD A Chamberlain
Jul 1, 1994·Postgraduate Medical Journal·R ShuklaJ E Pohl
Mar 26, 2015·BMJ Case Reports·David LedinghamShahid Junejo
Jan 1, 1987·European Journal of Clinical Pharmacology·O Van ReethJ Unger
Sep 1, 1986·The American Journal of the Medical Sciences·M SafranL E Braverman
May 1, 1985·American Heart Journal·E A RaederB Lown
Nov 1, 1984·American Heart Journal·A SanmartíJ Soler-Soler
Dec 1, 1989·The American Journal of Cardiology·J A OharC W Bedrossian
Jan 1, 1986·The American Journal of Cardiology·N Z KerinM Rubenfire
Jan 1, 1989·Progress in Cardiovascular Diseases·B N SinghR Kannan
Dec 1, 1976·The American Journal of Cardiology·M B RosenbaumM V Elizari
Oct 1, 1983·American Heart Journal·B N Singh
Sep 1, 1987·Clinical Endocrinology·J A FranklynM C Sheppard
Sep 1, 1987·Biopharmaceutics & Drug Disposition·S J Weir, C T Ueda
Jan 1, 1984·Pacing and Clinical Electrophysiology : PACE·B N SinghN Ikeda
Jun 1, 1984·The Journal of Pharmacy and Pharmacology·M R LallozR L Himsworth
Feb 1, 1987·Clinical Endocrinology·E MartinoA Pinchera
Apr 1, 1983·European Journal of Clinical Investigation·N M DebbasP Puech
Oct 8, 2005·Journal of Cardiovascular Pharmacology and Therapeutics·Nitin Wadhani, Bramah N Singh

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.