PMID: 3758001Jul 1, 1986Paper

Effects of amitraz, several opiate derivatives and anticholinergic agents on intestinal transit in ponies

Equine Veterinary Journal
M C Roberts, A Argenzio

Abstract

Amitraz, atropine, glycopyrrolate and morphine (but not its derivatives, meperidine [pethidine], oxymorphone and butorphanol) produced similar effects on clinically observed intestinal functions and significantly prolonged intestinal transit, as assessed with polyethylene glycol (PEG). However, their mechanisms of action, particularly on intestinal transport (fluid movement), may differ widely. Loperamide appeared to exert a preferential action on intestinal transport rather than motility, as there was no significant delay in PEG transit. The action of amitraz in perturbing smooth muscle coordination and enhancing absorption involved, at least partially, an alpha 2 adrenergic component susceptible to yohimbine. Naloxone, an opiate antagonist, did not influence amitraz responses but induced the return of intestinal sounds and defecation after a refractory period in morphine-dosed ponies. The results suggest potential clinical applications in horses for loperamide in diarrhoea therapy, for alpha 2 adrenergic antagonists in obstruction and ileus and, possibly, of amitraz-like agents in reducing fluid losses in diarrhoea.

References

Jan 1, 1982·Comparative Biochemistry and Physiology. C: Comparative Pharmacology·M A Pass, A A Seawright
Jun 1, 1984·Canadian Journal of Physiology and Pharmacology·A B Thomson
Jul 1, 1983·Equine Veterinary Journal·M C Roberts, A A Seawright

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Citations

Jan 1, 1991·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·M A Pass, T D Mogg
Jun 1, 1995·Journal of Veterinary Pharmacology and Therapeutics·M A Pass, T D Mogg
Jul 1, 1990·Equine Veterinary Journal·S G KamerlingC A Bagwell
Jun 3, 2006·American Journal of Veterinary Research·Pedro BoscanJack R Snyder
Jan 1, 1990·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·M KlingerR McCabe
Oct 26, 2005·The Veterinary Clinics of North America. Food Animal Practice·David C Van MetreFranklyn B Garry
Sep 11, 2004·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·J D Wood, J J Galligan
Apr 26, 2006·Veterinary Anaesthesia and Analgesia·Kate E Borer, K W Clarke
May 29, 2012·Australian Veterinary Journal·B M KayeS L Jalim
Feb 1, 2014·Journal of Veterinary Pharmacology and Therapeutics·H K KnychD S McKemie
May 1, 1987·Equine Veterinary Journal·B A Callingham, R B Williams
Jun 18, 2002·The Veterinary Clinics of North America. Equine Practice·Erin Malone, Lynelle Graham
Jun 18, 2002·The Veterinary Clinics of North America. Equine Practice·Rachel C Bennett, Eugene P Steffey
Nov 21, 2017·Journal of the American Veterinary Medical Association·Rita F WehrmanHeather L Chandler
Apr 14, 2004·American Journal of Veterinary Research·Francisco J Teixeira NetoSumit Duronghphongtorn
Apr 14, 2004·American Journal of Veterinary Research·Francisco J Teixeira NetoSumit Duronghphongtorn
Sep 24, 1999·Veterinary Surgery : VS·T J DohertyD L Frazier
Aug 8, 2021·Animals : an Open Access Journal From MDPI·Lucas Troya-PortilloIsabel Santiago-Llorente

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