PMID: 9551768Apr 29, 1998Paper

Effects of AMPA receptor antagonists on dopamine-mediated behaviors in mice

Psychopharmacology
K E Vanover

Abstract

Current data indicate that dopaminergic and glutamatergic neurotransmitter systems interact. The role of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) glutamate receptor subtypes in modulating dopamine neurotransmission, however, remains unclear. The noncompetitive AMPA antagonists, GYKI 52466 (5-40 mg/kg) and LY300164 (1-6 mg/kg), and the competitive AMPA antagonists, LY326325 (5-80 mg/kg) and NBQX (10-80 mg/kg), were compared to the dopamine antagonist, haloperidol (0.03-1.0 mg/kg), for their ability to inhibit dopamine-mediated behaviors after i.p. administration in mice. The behavioral paradigms included amphetamine- or dizocilpine-induced hyperactivity, amphetamine-induced stereotyped sniffing, and apomorphine-induced climbing and stereotyped sniffing. All four AMPA antagonists and haloperidol attenuated amphetamine- and dizocilpine-induced hyperactivity and decreased spontaneous locomotion. Haloperidol and GYKI 52466 were more potent against amphetamine than against dizocilpine. In contrast, LY326325 was more potent against dizocilpine than against amphetamine. The hyperactivity decreases by LY300164 and NBQX were most likely due to non-specific effects on motor behavior. The AMPA antagonists and haloper...Continue Reading

Citations

Apr 4, 2006·Intensive Care Medicine·Alfred AyalaMario Perl
Nov 17, 2001·European Journal of Pharmacology·R M KamińskiG Van Luijtelaar
May 24, 2003·Behavioural Processes·Silvânia M.M. VasconcelosGlauce S.B. Viana
Jan 5, 2002·Journal of Pharmacological and Toxicological Methods·R B RaffaR J Schulingkamp
Aug 29, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jing DuHusseini K Manji
Jan 22, 2014·Molecular Brain·Mie Kubota-SakashitaTadafumi Kato
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Aug 12, 2010·Neurobiology of Disease·Paul J FitzgeraldAndrew Holmes
Aug 20, 2005·Addiction Biology·Makoto FukumotoRyuzou Kawahara
Oct 14, 2017·International Journal of Bipolar Disorders·Dominik K E Beyer, Nadja Freund
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