PMID: 6413984Jul 1, 1983Paper

Effects of amphetamine and apomorphine on locomotor activity after 6-OHDA and electrolytic lesions of the nucleus accumbens septi

Pharmacology, Biochemistry, and Behavior
P H Kelly, D C Roberts

Abstract

Spontaneous locomotor activity was markedly elevated by electrolytic lesions of the nucleus accumbens. This was true whether or not the dopaminergic input to this nucleus was previously destroyed by injection of 6-hydroxydopamine (6-OHDA) into the region. In animals with electrolytic lesions the locomotor stimulant action of d-amphetamine sulfate (1.5 mg/kg SC) was occluded, while a moderately low dose of apomorphine (0.25 mg/kg SC) produced a striking decrease of locomotor activity. The results are consistent with the view that the efferents of neurons in the nucleus accumbens exert an inhibitory influence on locomotor activity. Hyperactivity results when these efferents are destroyed. The results are also consistent with the view that the locomotor depressant action of apomorphine is mediated, at least partly, by an action at a site other than the nucleus accumbens.

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Citations

Jun 1, 1985·Pharmacology, Biochemistry, and Behavior·K L KubosR G Robinson
Aug 1, 1988·Pharmacology, Biochemistry, and Behavior·I WeinerJ Feldon
Jan 1, 1988·Pharmacology, Biochemistry, and Behavior·S I DworkinJ E Smith
Oct 1, 1989·Pharmacology, Biochemistry, and Behavior·B A Mattingly, J K Rowlett
Sep 1, 1990·Pharmacology, Biochemistry, and Behavior·D F Emerich, T J Walsh
Apr 1, 1991·Pharmacology, Biochemistry, and Behavior·L S WongD M Jackson
May 1, 1991·Pharmacology, Biochemistry, and Behavior·K Antoniou, E Kafetzopoulos
Jan 1, 1992·Pharmacology, Biochemistry, and Behavior·C MessierC Destrade
Nov 1, 1992·Pharmacology, Biochemistry, and Behavior·K Antoniou, E Kafetzopoulos
Apr 1, 1993·Pharmacology, Biochemistry, and Behavior·M Konstandi, E Kafetzopoulos
Jan 1, 1994·Pharmacology & Therapeutics·D M Jackson, A Westlind-Danielsson
Mar 1, 1986·Brain Research·E Garcia-Rill
Feb 1, 1996·Behavioural Brain Research·C E Stern, R E Passingham
Dec 4, 1985·Neuroscience Letters·S L Hartgraves, P H Kelly
Nov 26, 2002·Behavioural Brain Research·Liat LevitaTrevor W Robbins
Jan 24, 2004·Behavioural Brain Research·Vanessa Erin Woods, Aaron Ettenberg
Apr 2, 1999·The European Journal of Neuroscience·D S ZahmJ R Martin
Apr 1, 1990·British Journal of Pharmacology·N Uchimura, R A North
Oct 22, 2008·Progress in Neuro-psychopharmacology & Biological Psychiatry·Pamela SabioniRoberto Andreatini
Mar 23, 2007·Progress in Neuro-psychopharmacology & Biological Psychiatry·R R HorsleyH J Cassaday
Dec 13, 1991·Behavioural Brain Research·P J Reading, S B Dunnett

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