PMID: 8950001Nov 1, 1996Paper

Effects of amphetamine, morphine and dizocilpine (MK-801) on spontaneous alternation in the 8-arm radial maze

Behavioural Brain Research
S M HölterW J Schmidt

Abstract

The induction of psychomotor activation, behavioural sensitization and of perseverative behaviours, resulting in reduced behavioural variability, have been proposed to be common properties of drugs of abuse. The present investigation tested whether these drug effects could be measured using spontaneous alternation in an 8-arm radial maze. Behavioural effects of repeated treatment with amphetamine (2 and 4 mg/kg, i.p.), morphine (1.25 and 10 mg/kg, i.p.) and the non-competitive NMDA receptor antagonist, MK-801 (0.1 and 0.2 mg/kg, i.p.), on spontaneous alternation were evaluated in this paradigm. All drugs induced psychomotor activation. Sensitized as well as reduced locomotor activity could be observed after repeated treatment depending on drug and dose. Analysis of the sequences of arm entries revealed that all drugs induced perseverative locomotor patterns, but the pattern induced by amphetamine and morphine differed qualitatively from the pattern induced by MK-801.

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Citations

Feb 12, 2002·Neuroscience and Biobehavioral Reviews·Robert Lalonde
Mar 23, 2004·Behavioural Brain Research·Jennifer M HorwoodDavid N Stephens
Sep 21, 2006·Human Molecular Genetics·Huu Phuc NguyenStephan von Hörsten
Jan 30, 2015·Bioprocess and Biosystems Engineering·Andreas Christoph Apel, Dirk Weuster-Botz
Jul 29, 2005·Journal of the Experimental Analysis of Behavior·Raymond C Pitts, A Patrick McKinney

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