PMID: 3762938Oct 1, 1986Paper

Effects of amyotrophic lateral sclerosis serum on cultured chick spinal neurons

Neurology
P DohertyF S Walsh

Abstract

We used a quantitative immunoassay to examine the effects of human serum and immunoglobulins on neurofilament protein expression in cultures of chick spinal neurons. Compared with cultures grown in the presence of serum from healthy controls or patients with other neurologic disorders, ALS serum lowered the level of neurofilament proteins. Effects were similar with or without muscle-derived neurotrophic factors; there was no specificity for motor neurons. No neurotoxic activity was found in immunoglobulin fractions, and there was no evidence of circulating antibodies that might neutralize muscle-derived neurotrophic factors or induce cytolysis of spinal neurons.

Citations

Oct 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·O D UchitelL Sczcupak
Jan 1, 1991·Mayo Clinic Proceedings·D B Williams, A J Windebank
Aug 27, 2010·Neurología : publicación oficial de la Sociedad Española de Neurología·J Matías-GuiuA Guerrero
Mar 1, 1992·Acta Neurologica Scandinavica·J Martí-FàbregasI Illa
Apr 6, 2021·Frontiers in Molecular Neuroscience·Koy Chong Ng Kee KwongArpan R Mehta

❮ Previous
Next ❯

Related Concepts

Related Feeds

Amyloid Lateral Sclerosis

Amyotrophic Lateral Sclerosis (ALS) is a progressive nervous system disease associated with the death of neurons that control voluntary muscles. Discover the latest research on ALS here.