Effects of an 8-Week Protein Supplementation Regimen with Hyperimmunized Cow Milk on Exercise-Induced Organ Damage and Inflammation in Male Runners: A Randomized, Placebo Controlled, Cross-Over Study

Biomedicines
Sihui MaKatsuhiko Suzuki

Abstract

Prolonged strenuous exercise may induce inflammation, cause changes in gastrointestinal permeability, and lead to other unfavorable biological changes and diseases. Nutritional approaches have been used to prevent exercise-induced inflammatory responses and gastrointestinal disorders. Hyperimmunized milk, obtained by immunizing cows against specific antigens, promotes the development of immunity against pathogens, promotes anti-inflammatory effects, and protects intestinal function. Immune protein (IMP) is a concentrated product of hyperimmunized milk and is a more promising means of supplementation to protect against acute infections and inflammation. To determine whether IMP has protective properties against exercise-induced gastrointestinal dysfunction and inflammation, we examined biochemical markers, intestinal damage markers, and pro-/anti-inflammatory profiles of young male runners using a randomized, placebo controlled, cross-over design. Urine samples were collected and used for measurements of creatinine, N-acetyl-β-d-glucosaminidase, osmotic pressure, and specific gravity. Titin was measured as a muscle damage marker. Further, urine concentrations of complement 5a, calprotectin, fractalkine, myeloperoxidase, macropha...Continue Reading

References

Jul 1, 1992·Journal of Pediatric Gastroenterology and Nutrition·O BrunserH Brüssow
Sep 1, 1990·British Journal of Sports Medicine·A E DonnellyP H Whiting
Jan 1, 1989·Proceedings of the Society for Experimental Biology and Medicine·W E Owens, S C Nickerson
Feb 1, 1994·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·C T CordleM A Hirsch
Jun 1, 1994·Annals of Emergency Medicine·R SinertT Scalea
Jun 24, 1998·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·P C OkhuysenH L DuPont
Feb 15, 2001·Journal of Pediatric Gastroenterology and Nutrition·S A SarkerL Hammarström
May 18, 2001·Journal of Applied Physiology·G P LambertC V Gisolfi
Apr 9, 2005·The American Journal of Clinical Nutrition·Lisa A SpenceConnie M Weaver
Nov 11, 2006·Journal of Applied Physiology·Cecilia M ShingJeff S Coombes
Apr 17, 2007·International Journal of Sports Medicine·G P LambertS Lanspa
Nov 19, 2008·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Cecilia M ShingJeff S Coombes
Aug 5, 2011·International Journal of Sport Nutrition and Exercise Metabolism·Manuela KonradSandra J Wallner-Liebmann
Oct 24, 2013·European Journal of Applied Physiology·Cecilia M ShingLuis Vitetta
Feb 24, 2016·Recent Patents on Inflammation & Allergy Drug Discovery·Ramesh YadavHarpal S Buttar
Oct 30, 2016·International Journal of Sport Nutrition and Exercise Metabolism·Dana LisJames Fell
Jul 1, 2016·The American Journal of Clinical Nutrition·Glen DavisonRaymond J Playford
Dec 3, 2016·Journal of Applied Physiology·Jonathan M PeakeRichard J Simpson
May 17, 2017·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Jamie N PughGraeme L Close
Jun 8, 2017·Alimentary Pharmacology & Therapeutics·R J S CostaP R Gibson
Feb 20, 2018·Journal of Dairy Science·Lan-Hsin HungLucy Sun Hwang
Oct 28, 2018·Allergology International : Official Journal of the Japanese Society of Allergology·Daisuke TokuharaHiroshi Kiyono
Nov 13, 2018·International Journal of Sports Medicine·Jaak JürimäePriit Purge

❮ Previous
Next ❯

Methods Mentioned

BETA
enzyme-linked immunosorbent assay
ELISA

Software Mentioned

GraphPad
Power

Related Concepts

Related Feeds

Alternative Complement Pathway

The Alternative Complement Pathway is part of the innate immune system, and activation generates membrane attack complexes that kill pathogenic cells. Discover the latest research on the Alternative Complement Pathway.