Abstract
Previous study by the current authors has shown that treating homes with D'Allergen, an acaricidal agent, can reduce bronchial hyper-reactivity in asthmatic children with house dust mite allergy. In the present study, the effects of a single D'Allergen treatment on the levels of major dust mite allergens, Der p I and Der f I was evaluated, and the duration of its effectiveness in the environment determined. Twenty randomly selected homes were treated with the acaricide and ten remained untreated. Dust samples were collected from mattresses, upholstered sofas and carpets of these homes before and 1, 2 and 4 months after treatment. The samples were then assayed for Der p I and Der f I allergens using a sandwich enzyme immunoassay. The results showed that D'Allergen was effective in reducing dust mite allergen levels in all three niches by 1.5-22.3 times below baseline values. This effect, however, was only present for 2 months, and the dust mite allergen levels increased to those of the baseline by the fourth month after treatment. These results indicated that repeated applications of the acaricide were required at 2-3 monthly intervals to obtain optimal effectiveness.
References
Oct 1, 1992·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·B J HartN Nolard
Jan 1, 1992·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·E R ToveyA Woolcock
Jul 1, 1992·The Journal of Allergy and Clinical Immunology·B EhnertU Wahn
Feb 1, 1992·The Journal of Allergy and Clinical Immunology·M L HaydenT A Platts-Mills
Nov 1, 1989·The Journal of Allergy and Clinical Immunology·S LauU Wahn
Aug 1, 1987·The Journal of Allergy and Clinical Immunology·M D ChapmanT A Platts-Mills
Sep 25, 1982·Lancet·T A Platts-MillsS R Wilkins
Jul 21, 1984·Lancet·W F Green
Mar 1, 1982·The Journal of Allergy and Clinical Immunology·D VervloetJ Charpin
Nov 1, 1994·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·G B MarksA J Woolcock
Dec 1, 1994·Allergy·T M ZheltikovaG N Stepanova
Dec 1, 1994·Acta Paediatrica Japonica; Overseas Edition·S C QuekB W Lee
Apr 1, 1993·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·J A WarnerJ O Warner
Mar 1, 1993·The Journal of Allergy and Clinical Immunology·A DietemannG Pauli
Jun 17, 1999·Allergy·F T ChewB W Lee
Citations
Mar 8, 2003·The Journal of School Health·Howard Taras, Jack Campana
Apr 18, 2002·Allergologia et immunopathologia·A MaletM G Pueyo Mf
Feb 9, 1999·The Journal of Allergy and Clinical Immunology·E Tovey, G Marks
Apr 22, 2008·The Cochrane Database of Systematic Reviews·P C Gøtzsche, H K Johansen